Literature DB >> 15960536

Enhanced peptide beta-sheet affinity by metal to ligand coordination.

Michael Kruppa1, Christoph Bonauer, Veronika Michlová, Burkhard König.   

Abstract

A histidine-coordinating metal complex substituted with methoxypyrrole amino acids (MOPAS) as a peptide beta-sheet binder shows high affinity for a H(2)N-His-Leu-Leu-Val-Phe-OMe pentapeptide in DMSO solution. Within the complex, a beta-sheet conformation is induced into the pentapeptide by weak intra-assembly interactions with the MOPAS units.

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Year:  2005        PMID: 15960536     DOI: 10.1021/jo0502908

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  2 in total

Review 1.  Synthetic mimetics of protein secondary structure domains.

Authors:  Nathan T Ross; William P Katt; Andrew D Hamilton
Journal:  Philos Trans A Math Phys Eng Sci       Date:  2010-03-13       Impact factor: 4.226

Review 2.  Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.

Authors:  Marta Pelay-Gimeno; Adrian Glas; Oliver Koch; Tom N Grossmann
Journal:  Angew Chem Int Ed Engl       Date:  2015-06-26       Impact factor: 15.336

  2 in total

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