Literature DB >> 15959857

A prospective study of serum ghrelin levels in patients treated with clozapine.

F M Theisen1, S Gebhardt, T Brömel, B Otto, W Heldwein, M Heinzel-Gutenbrunner, J-C Krieg, H Remschmidt, M Tschöp, J Hebebrand.   

Abstract

We investigated serum ghrelin levels (SGL) in 12 patients with schizophrenia over a 10-week period after initiation of clozapine treatment. In contrast to increments of body mass indices (BMI, kg/m2) and serum leptin levels (SLL), no significant change in SGL was detected. Inverse correlations between delta SGL and delta SLL did not reach statistical significance. Linear mixed model analysis could not detect effects of age, sex, BMI, SLL and serum clozapine levels on SGL. Our results do not support a causal involvement of ghrelin in clozapine-related weight gain.

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Year:  2005        PMID： 15959857     DOI： 10.1007/s00702-005-0284-6

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  16 in total

1.  Serum ghrelin concentrations in patients receiving olanzapine or risperidone.

Authors:  Takashi Togo; Koichi Hasegawa; Satoshi Miura; Hideki Hosojima; Katsuo Kojima; Mika Shoji; Akihiko Kase; Hirotake Uchikado; Eizo Iseki; Kenji Kosaka
Journal:  Psychopharmacology (Berl)       Date:  2003-10-09       Impact factor: 4.530

Review 2.  Antipsychotic-induced weight gain: a comprehensive research synthesis.

Authors:  D B Allison; J L Mentore; M Heo; L P Chandler; J C Cappelleri; M C Infante; P J Weiden
Journal:  Am J Psychiatry       Date:  1999-11       Impact factor: 18.112

3.  Clozapine-induced weight gain: prevalence and clinical relevance.

Authors:  R Leadbetter; M Shutty; D Pavalonis; V Vieweg; P Higgins; M Downs
Journal:  Am J Psychiatry       Date:  1992-01       Impact factor: 18.112

4.  Serum leptin levels increase rapidly after initiation of clozapine therapy.

Authors:  T Brömel; W F Blum; A Ziegler; E Schulz; M Bender; C Fleischhaker; H Remschmidt; J C Krieg; J Hebebrand
Journal:  Mol Psychiatry       Date:  1998-01       Impact factor: 15.992

5.  Body weight gain after administration of antipsychotic drugs: correlation with leptin, insulin and reproductive hormones.

Authors:  T Baptista; A Lacruz; S de Mendoza; J M Mendoza Guillén; R Silvera; F Angeles; M T Mendoza; L Hernández
Journal:  Pharmacopsychiatry       Date:  2000-05       Impact factor: 5.788

6.  Determination of clozapine and its major metabolites in serum samples of adolescent schizophrenic patients by high-performance liquid chromatography. Data from a prospective clinical trial.

Authors:  E Schulz; C Fleischhaker; H Remschmidt
Journal:  Pharmacopsychiatry       Date:  1995-01       Impact factor: 5.788

7.  Ghrelin induces adiposity in rodents.

Authors:  M Tschöp; D L Smiley; M L Heiman
Journal:  Nature       Date:  2000-10-19       Impact factor: 49.962

8.  Circulating ghrelin levels are decreased in human obesity.

Authors:  M Tschöp; C Weyer; P A Tataranni; V Devanarayan; E Ravussin; M L Heiman
Journal:  Diabetes       Date:  2001-04       Impact factor: 9.461

9.  Body weight and leptin plasma levels during treatment with antipsychotic drugs.

Authors:  T Kraus; M Haack; A Schuld; D Hinze-Selch; M Kühn; M Uhr; T Pollmächer
Journal:  Am J Psychiatry       Date:  1999-02       Impact factor: 18.112

10.  Serum leptin and triglyceride levels in patients on treatment with atypical antipsychotics.

Authors:  Murad Atmaca; Murat Kuloglu; Ertan Tezcan; Bilal Ustundag
Journal:  J Clin Psychiatry       Date:  2003-05       Impact factor: 4.384
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  9 in total

1.  Is There Such Thing as a Schizophrenic Stomach?

Authors:  Igor Elman; David Borsook; Scott E Lukas
Journal:  Neuropsychopharmacology       Date:  2006       Impact factor: 7.853

Review 2.  Atypical antipsychotic-induced weight gain: insights into mechanisms of action.

Authors:  James L Roerig; Kristine J Steffen; James E Mitchell
Journal:  CNS Drugs       Date:  2011-12-01       Impact factor: 5.749

3.  Antipsychotic-induced changes in blood levels of leptin in schizophrenia: a meta-analysis.

Authors:  Stéphane Potvin; Simon Zhornitsky; Emmanuel Stip
Journal:  Can J Psychiatry       Date:  2015-03       Impact factor: 4.356

Review 4.  Impact of atypical antipsychotic therapy on leptin, ghrelin, and adiponectin.

Authors:  Hua Jin; Jonathan M Meyer; Sunder Mudaliar; Dilip V Jeste
Journal:  Schizophr Res       Date:  2008-01-18       Impact factor: 4.939

Review 5.  [Atypical antipsychotics and metabolic syndrome].

Authors:  Andreas Baranyi; Renè Yazdani; Alexandra Haas-Krammer; Alexandra Stepan; Hans-Peter Kapfhammer; Hans-Bernd Rothenhäusler
Journal:  Wien Med Wochenschr       Date:  2007

Review 6.  Pharmacological management of atypical antipsychotic-induced weight gain.

Authors:  Trino Baptista; Yamily ElFakih; Euderruh Uzcátegui; Ignacio Sandia; Eduardo Tálamo; Enma Araujo de Baptista; Serge Beaulieu
Journal:  CNS Drugs       Date:  2008       Impact factor: 5.749

7.  The role of leptin in antipsychotic-induced weight gain: genetic and non-genetic factors.

Authors:  Fabio Panariello; Gina Polsinelli; Carol Borlido; Marcellino Monda; Vincenzo De Luca
Journal:  J Obes       Date:  2012-03-07

Review 8.  Leptin and ghrelin levels in patients with schizophrenia during different antipsychotics treatment: a review.

Authors:  Othman Sentissi; Jacques Epelbaum; Jean-Pierre Olié; Marie-France Poirier
Journal:  Schizophr Bull       Date:  2007-12-28       Impact factor: 9.306

9.  The TNF-alpha system: functional aspects in depression, narcolepsy and psychopharmacology.

Authors:  Mark Berthold-Losleben; Hubertus Himmerich
Journal:  Curr Neuropharmacol       Date:  2008-09       Impact factor: 7.363
  9 in total

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