| Literature DB >> 15958675 |
Taichiro Takemura1, Michel Ekwalanga2, Blaise Bikandou3, Eiji Ido1, Yumi Yamaguchi-Kabata4, Sadayuki Ohkura1, Hirotada Harada1, Jun Takehisa5, Hiroshi Ichimura5, Henri-Joseph Parra3, Monique Nende6, Eric Mubwo6, Midingi Sepole6, Masanori Hayami1, Tomoyuki Miura1.
Abstract
In order to understand primate lentivirus evolution, characterization of additional simian immunodeficiency virus (SIV) strains is essential. Here, an SIV from a black mangabey (Lophocebus aterrimus) originating from the Democratic Republic of Congo was analysed phylogenetically. The monkey had cross-reactive antibodies against human immunodeficiency virus type 1 (HIV-1) and HIV-2. The viral pol region sequence was amplified by nested PCR and sequence analysis confirmed that it was related to known SIV sequences. This is the first report to characterize genetically an SIV from the monkey genus Lophocebus. Phylogenetic analysis of the pol region revealed that this novel SIV, designated SIVbkm, fell into the SIVsyk and SIVgsn virus group, containing viruses isolated from the genus Cercopithecus, and suggests that cross-species transmission has occurred between species of the genera Lophocebus and Cercopithecus.Entities:
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Year: 2005 PMID： 15958675 DOI： 10.1099/vir.0.80697-0
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891