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Literature DB >> 15957933

Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica.

Greg O Buchanan¹, Philip G Williams, Robert H Feling, Christopher A Kauffman, Paul R Jensen, William Fenical.

Abstract

[structure: see text] Analysis of the fermentation broth of a strain of the marine actinomycete Salinispora tropica has led to the isolation of two unprecedented macrolides, sporolides A (1) and B (2). The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography.

Entities: Chemical Species

Mesh：

Substances：
Macrolides
sporolide A

Year: 2005 PMID： 15957933 DOI： 10.1021/ol050901i

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

43 in total

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Review 2. Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

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4. Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora.

Authors: Paul R Jensen; Philip G Williams; Dong-Chan Oh; Lisa Zeigler; William Fenical
Journal: Appl Environ Microbiol Date: 2006-12-08 Impact factor: 4.792

Review 5. What's new in enzymatic halogenations.

Authors: Danica Galonić Fujimori; Christopher T Walsh
Journal: Curr Opin Chem Biol Date: 2007-09-18 Impact factor: 8.822

6. A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis.

Authors: Jian Zhang; Steven G Van Lanen; Jianhua Ju; Wen Liu; Pieter C Dorrestein; Wenli Li; Neil L Kelleher; Ben Shen
Journal: Proc Natl Acad Sci U S A Date: 2008-01-25 Impact factor: 11.205

Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica.

Review 1. Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.

Review 2. Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

3. Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery.

4. Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora.

Review 5. What's new in enzymatic halogenations.

6. A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis.

7. Marine natural products: a new wave of drugs?

Review 8. Biosynthesis and function of polyacetylenes and allied natural products.

Review 9. Antitumor compounds from marine actinomycetes.

10. Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria.