Literature DB >> 15957031

Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha.

Rong-Tao Li1, Quan-Bin Han, Yong-Tang Zheng, Rui-Rui Wang, Liu-Meng Yang, Yang Lu, Su-Qin Sang, Qi-Tai Zheng, Qin-Shi Zhao, Han-Dong Sun.   

Abstract

Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C, were isolated from Schisandra micrantha; micrandilactone C exhibited an EC50 value of 7.71 microg/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of make it a promising lead for therapeutic development of a new generation of anti-HIV drug.

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Year:  2005        PMID： 15957031     DOI： 10.1039/b501932j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Assignment of the absolute configuration of hepatoprotective highly oxygenated triterpenoids using X-ray, ECD, NMR J-based configurational analysis and HSQC overlay experiments.

Authors:  Xiaojuan Wang; Jiabao Liu; Pankaj Pandey; Jiabao Chen; Frank R Fronczek; Stuart Parnham; Xinzhu Qi; Robert J Doerksen; Daneel Ferreira; Hua Sun; Shuai Li; Mark T Hamann
Journal:  Biochim Biophys Acta Gen Subj       Date:  2017-09-15       Impact factor: 3.770

Review 2.  Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents.

Authors:  Reen-Yen Kuo; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Nat Prod Rep       Date:  2009-08-13       Impact factor: 13.423

3.  Calixpyrrole derivatives: "multi hydrogen bond" catalysts for gamma-butenolide synthesis.

Authors:  Grazia Cafeo; Margherita De Rosa; Franz H Kohnke; Annunziata Soriente; Carmen Talotta; Luca Valenti
Journal:  Molecules       Date:  2009-07-15       Impact factor: 4.411

4.  Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-Type Nortriterpenoid Using X-Ray Diffraction.

Authors:  Xiaojuan Wang; Frank R Fronczek; Jiabao Chen; Jiabao Liu; Daneel Ferreira; Shuai Li; Mark T Hamann
Journal:  Molecules       Date:  2017-01-02       Impact factor: 4.411

Review 5.  Harvest, After 50 Years of Sowing.

Authors:  Pema-Tenzin Puno
Journal:  Nat Prod Bioprospect       Date:  2018-07-19

Review 6.  Application of Pauson-Khand reaction in the total synthesis of terpenes.

Authors:  Majid M Heravi; Leila Mohammadi
Journal:  RSC Adv       Date:  2021-11-29       Impact factor: 4.036
  6 in total

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