[Non-manifested stages of schizophrenia: psychopathology and therapy].

Presented is a hypothesis that allows to interpret non-manifested stages of schizophrenia: prodromes and remissions characterized negative schizophrenia and reflected a slow progress of the endogenous process; formation of residual states indicated a change of stereotypy of development of the disease with attenuation of its destructive tendencies and transition to evolution, comparable to personality disorders dynamics. Using clinically differentiated models (the dimensional model of schizophrenia and model of personality disorders dynamics), the arguments for the hypothesis are presented. According to this hypothesis, a dual-purpose psychopharmacotherapeutic model appears to be an optimal strategy. One of the therapeutic aims is arrest of psychosis; the other is preventing, or at least delaying, manifestation or next exacerbation of positive disorders and slowing down the disease progression in the non-psychotic stages.