Literature DB >> 15953827

Environmental toxins and alpha-synuclein in Parkinson's disease.

Yanying Liu1, Hui Yang.   

Abstract

In recent years, environmental influences have been thought to play an important role in Parkinson's disease (PD). Evidence from epidemiological investigations suggests that environmental factors might take part in the disease process. Intriguingly, most of environmental toxins share the common mechanism of causing mitochondria dysfunction by inhibiting complex I and promoting alpha-synuclein aggregation, a key factor in PD. Therefore, understanding the mechanism of interactions between alpha-synuclein and environmental factors could lead to new therapeutic approaches to PD.

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Year:  2005        PMID： 15953827     DOI： 10.1385/MN:31:1-3:273

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  66 in total

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Authors:  Ulf T Brunk; Alexei Terman
Journal:  Eur J Biochem       Date:  2002-04

Review 2.  Mitochondrial involvement in Parkinson's disease.

Authors:  M Orth; A H V Schapira
Journal:  Neurochem Int       Date:  2002-05       Impact factor: 3.921

3.  Nuclear localization of alpha-synuclein and its interaction with histones.

Authors:  John Goers; Amy B Manning-Bog; Alison L McCormack; Ian S Millett; Sebastian Doniach; Donato A Di Monte; Vladimir N Uversky; Anthony L Fink
Journal:  Biochemistry       Date:  2003-07-22       Impact factor: 3.162

Review 4.  Mechanistic approaches to Parkinson's disease pathogenesis.

Authors:  Ranjita Betarbet; Todd B Sherer; Donato A Di Monte; J Timothy Greenamyre
Journal:  Brain Pathol       Date:  2002-10       Impact factor: 6.508

Review 5.  Proteolytic stress: a unifying concept for the etiopathogenesis of Parkinson's disease.

Authors:  Kevin St P McNaught; C Warren Olanow
Journal:  Ann Neurol       Date:  2003       Impact factor: 10.422

6.  Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease.

Authors:  Jin Xu; Shyan-Yuan Kao; Frank J S Lee; Weihong Song; Lee-Way Jin; Bruce A Yankner
Journal:  Nat Med       Date:  2002-06       Impact factor: 53.440

7.  The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein.

Authors:  Amy B Manning-Bog; Alison L McCormack; Jie Li; Vladimir N Uversky; Anthony L Fink; Donato A Di Monte
Journal:  J Biol Chem       Date:  2001-11-13       Impact factor: 5.157

8.  An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.

Authors:  Todd B Sherer; Ranjita Betarbet; Amy K Stout; Serena Lund; Melisa Baptista; Alexander V Panov; Mark R Cookson; J Timothy Greenamyre
Journal:  J Neurosci       Date:  2002-08-15       Impact factor: 6.167

9.  Alpha-synuclein expression in HEK293 cells enhances the mitochondrial sensitivity to rotenone.

Authors:  M Orth; S J Tabrizi; A H V Schapira; J M Cooper
Journal:  Neurosci Lett       Date:  2003-11-06       Impact factor: 3.046

Review 10.  Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. a review.

Authors:  Richard M Kostrzewa; Juan Segura-Aguilar
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.978
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  5 in total

Review 1.  Generation of reactive oxygen species by mitochondrial complex I: implications in neurodegeneration.

Authors:  Romana Fato; Christian Bergamini; Serena Leoni; Paola Strocchi; Giorgio Lenaz
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Review 2.  Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases.

Authors:  Latha Devi; Hindupur K Anandatheerthavarada
Journal:  Biochim Biophys Acta       Date:  2009-07-18

3.  Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease.

Authors:  L Lim; V Jackson-Lewis; L C Wong; G H Shui; A X H Goh; S Kesavapany; A M Jenner; M Fivaz; S Przedborski; M R Wenk
Journal:  Cell Death Differ       Date:  2011-08-05       Impact factor: 15.828

4.  Parkinson's disease in relation to pesticide exposure and nuclear encoded mitochondrial complex I gene variants.

Authors:  Elizabeth H Corder; George D Mellick
Journal:  J Biomed Biotechnol       Date:  2006

Review 5.  Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson's Disease: The Emerging Role of VDAC.

Authors:  Pierpaolo Risiglione; Federica Zinghirino; Maria Carmela Di Rosa; Andrea Magrì; Angela Messina
Journal:  Biomolecules       Date:  2021-05-11
  5 in total

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