Michael A Sandberg1, Alexander R Gaudio, Eliot L Berson. 1. Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, 02114, USA. masandberg@aol.com
Abstract
PURPOSE: To estimate the mean rates of decline of ocular function in patients with an atypical form of retinitis pigmentosa, termed "pericentral retinitis pigmentosa." DESIGN: Retrospective observational study. METHODS: setting: Single-center. patient population: Eighteen patients (ages 32 to 65 years) with pericentral retinitis pigmentosa followed for 3 to 26 years. observational procedures: Snellen visual acuity, Goldmann visual field area (V-4e white test light), and full-field electroretinogram (ERG) amplitudes (0.5 Hz and 30 Hz white flashes). main outcome measures: Mean annual exponential rates of change quantified by repeated-measures longitudinal regression. RESULTS: Estimated mean annual rates of decline of remaining ocular function were 1.2% for visual acuity, 1.9% for visual field area, 2.5% for ERG amplitude to 0.5 Hz flashes, and 2.9% for ERG amplitude to 30 Hz flashes. CONCLUSIONS: The mean rates of loss of remaining ocular function of patients with pericentral retinitis pigmentosa were generally slower than those previously reported for patients with typical forms of retinitis pigmentosa.
PURPOSE: To estimate the mean rates of decline of ocular function in patients with an atypical form of retinitis pigmentosa, termed "pericentral retinitis pigmentosa." DESIGN: Retrospective observational study. METHODS: setting: Single-center. patient population: Eighteen patients (ages 32 to 65 years) with pericentral retinitis pigmentosa followed for 3 to 26 years. observational procedures: Snellen visual acuity, Goldmann visual field area (V-4e white test light), and full-field electroretinogram (ERG) amplitudes (0.5 Hz and 30 Hz white flashes). main outcome measures: Mean annual exponential rates of change quantified by repeated-measures longitudinal regression. RESULTS: Estimated mean annual rates of decline of remaining ocular function were 1.2% for visual acuity, 1.9% for visual field area, 2.5% for ERG amplitude to 0.5 Hz flashes, and 2.9% for ERG amplitude to 30 Hz flashes. CONCLUSIONS: The mean rates of loss of remaining ocular function of patients with pericentral retinitis pigmentosa were generally slower than those previously reported for patients with typical forms of retinitis pigmentosa.
Authors: Rodrigo Matsui; Artur V Cideciyan; Sharon B Schwartz; Alexander Sumaroka; Alejandro J Roman; Malgorzata Swider; Wei Chieh Huang; Rebecca Sheplock; Samuel G Jacobson Journal: Invest Ophthalmol Vis Sci Date: 2015-09 Impact factor: 4.799
Authors: Anil Chekuri; Aditya A Guru; Pooja Biswas; Kari Branham; Shyamanga Borooah; Angel Soto-Hermida; Michael Hicks; Naheed W Khan; Hiroko Matsui; Akhila Alapati; Pongali B Raghavendra; Susanne Roosing; Sripriya Sarangapani; Sinnakaruppan Mathavan; Amalio Telenti; John R Heckenlively; S Amer Riazuddin; Kelly A Frazer; Paul A Sieving; Radha Ayyagari Journal: Hum Genet Date: 2018-07-05 Impact factor: 4.132
Authors: Jason Comander; Carol Weigel-DiFranco; Matthew Maher; Emily Place; Aliete Wan; Shyana Harper; Michael A Sandberg; Daniel Navarro-Gomez; Eric A Pierce Journal: Genes (Basel) Date: 2017-10-05 Impact factor: 4.096