Literature DB >> 15953552

Tropomyosin isoforms: divining rods for actin cytoskeleton function.

Peter W Gunning1, Galina Schevzov, Anthony J Kee, Edna C Hardeman.   

Abstract

Actin filament functional diversity is paralleled by variation in the composition of isoforms of tropomyosin in these filaments. Although the role of tropomyosin is well understood in skeletal muscle, where it regulates the actin-myosin interaction, its role in the cytoskeleton has been obscure. The intracellular sorting of tropomyosin isoforms indicated a role in spatial specialization of actin filament function. Genetic manipulation and protein chemistry studies have confirmed that these isoforms are functionally distinct. Tropomyosins differ in their recruitment of myosin motors and their interaction with actin filament regulators such as ADF-cofilin. Tropomyosin isoforms have therefore provided a powerful mechanism to diversify actin filament function in different intracellular compartments.

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Year:  2005        PMID： 15953552     DOI： 10.1016/j.tcb.2005.04.007

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  124 in total

1.  Tropomyosin isoforms and reagents.

Authors:  Galina Schevzov; Shane P Whittaker; Thomas Fath; Jim Jc Lin; Peter W Gunning
Journal:  Bioarchitecture       Date:  2011-07-01

2.  The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast.

Authors:  Arthur T Coulton; Daniel A East; Agnieszka Galinska-Rakoczy; William Lehman; Daniel P Mulvihill
Journal:  J Cell Sci       Date:  2010-08-31       Impact factor: 5.285

3.  Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands.

Authors:  Duncan Sousa; Anthony Cammarato; Ken Jang; Philip Graceffa; Larry S Tobacman; Xiaochuan Edward Li; William Lehman
Journal:  Biophys J       Date:  2010-08-04       Impact factor: 4.033

4.  Tropomyosin isoform modulation of focal adhesion structure and cell migration.

Authors:  Cuc T T Bach; Galina Schevzov; Nicole S Bryce; Peter W Gunning; Geraldine M O'Neill
Journal:  Cell Adh Migr       Date:  2010-04-07       Impact factor: 3.405

5.  Dual roles of tropomyosin as an F-actin stabilizer and a regulator of muscle contraction in Caenorhabditis elegans body wall muscle.

Authors:  Robinson Yu; Shoichiro Ono
Journal:  Cell Motil Cytoskeleton       Date:  2006-11

6.  Control of the initiation and termination of kinesin-1-driven transport by myosin-Ic and nonmuscle tropomyosin.

Authors:  Betsy B McIntosh; Erika L F Holzbaur; E Michael Ostap
Journal:  Curr Biol       Date:  2015-02-05       Impact factor: 10.834

7.  Differential interaction of cardiac, skeletal muscle, and yeast tropomyosins with fluorescent (pyrene235) yeast actin.

Authors:  Weizu Chen; Kuo-Kuang Wen; Ashley E Sens; Peter A Rubenstein
Journal:  Biophys J       Date:  2005-12-02       Impact factor: 4.033

8.  Top-down targeted proteomics for deep sequencing of tropomyosin isoforms.

Authors:  Ying Peng; Xin Chen; Han Zhang; Qingge Xu; Timothy A Hacker; Ying Ge
Journal:  J Proteome Res       Date:  2012-12-20       Impact factor: 4.466

9.  Analysis of tarantula skeletal muscle protein sequences and identification of transcriptional isoforms.

Authors:  Jingui Zhu; Yongqiao Sun; Fa-Qing Zhao; Jun Yu; Roger Craig; Songnian Hu
Journal:  BMC Genomics       Date:  2009-03-19       Impact factor: 3.969

10.  Mutations of tropomyosin 3 (TPM3) are common and associated with type 1 myofiber hypotrophy in congenital fiber type disproportion.

Authors:  Michael W Lawlor; Elizabeth T Dechene; Emily Roumm; Amelia S Geggel; Behzad Moghadaszadeh; Alan H Beggs
Journal:  Hum Mutat       Date:  2010-02       Impact factor: 4.878
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