| Literature DB >> 15953536 |
Yanxing Liu1, Xuepei Li, Changsheng Ma, Junxiu Liu, Hong Lu.
Abstract
To investigate the effects of the tinnitus inducer sodium salicylate on L-type voltage-gated calcium channels, we studied freshly dissociated inferior colliculus neurons of rats by the whole-cell voltage clamp method. Salicylate's blocking of L-type calcium channels was concentration dependent, and the IC(50) value of salicylate was estimated to be 1.99 mM. An amount of 1 mM salicylate significantly shifted the steady-state inactivation curve of L-type calcium channels about 9 mV in the hyperpolarizing direction and significantly delayed calcium channel recovery. Our results suggest that salicylate's blocking of L-type calcium channels may contribute to salicylate-induced tinnitus by decreasing GABA release in the inferior colliculus.Entities:
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Year: 2005 PMID： 15953536 DOI： 10.1016/j.heares.2005.03.028
Source DB: PubMed Journal: Hear Res ISSN： 0378-5955 Impact factor: 3.208