Tomohiro Saijo1, Keiko Hayashi, Hideyuki Yamada, Masato Wakakura. 1. Department of Ophthalmology, Tokyo University School of Medicine, and Kawakita General Hospital, 1-7-3 Asagayakita, Suginami, Tokyo 166-8658, Japan. paul@d4.dion.ne.jp
Abstract
PURPOSE: To report a case of optic neuropathy associated with prolonged use of a new antibiotic, linezolid. DESIGN: Interventional case report. METHODS: Optic and peripheral neuropathy occurred in a 27-year-old woman who was undergoing prolonged linezolid therapy for osteomyelitis. The use of corticosteroid exacerbated visual loss. Discontinuation of the linezolid therapy resulted in marked improvement of optic neuropathy. RESULTS: Linezolid-induced optic neuropathy was diagnosed in this case, because prolonged linezolid therapy was performed at a higher dose than usual and because the patient recovered after linezolid therapy was discontinued. CONCLUSIONS: With prolonged linezolid therapy, ophthalmologists should be aware that bilateral optic neuropathy can occur and that corticosteroids are not indicated for this neuropathy.
PURPOSE: To report a case of optic neuropathy associated with prolonged use of a new antibiotic, linezolid. DESIGN: Interventional case report. METHODS: Optic and peripheral neuropathy occurred in a 27-year-old woman who was undergoing prolonged linezolid therapy for osteomyelitis. The use of corticosteroid exacerbated visual loss. Discontinuation of the linezolid therapy resulted in marked improvement of optic neuropathy. RESULTS:Linezolid-induced optic neuropathy was diagnosed in this case, because prolonged linezolid therapy was performed at a higher dose than usual and because the patient recovered after linezolid therapy was discontinued. CONCLUSIONS: With prolonged linezolid therapy, ophthalmologists should be aware that bilateral optic neuropathy can occur and that corticosteroids are not indicated for this neuropathy.