Literature DB >> 15952033

TRPV4 as osmosensor: a transgenic approach.

Wolfgang Liedtke1.   

Abstract

The transient receptor potential vanilloid 4 (TRPV4) ion channel was named initially vanilloid-receptor-related osmotically activated channel (VR-OAC). Preliminary answers to the question, "What is the function of the trpv4 gene in live animals ?" are highlighted briefly in this review. In trpv4 null mice, TRPV4 is necessary for the maintenance of osmotic equilibrium, and in Caenorhabditis elegans transgenic for mammalian TRPV4, TRPV4 directs the osmotic avoidance response in the context of the ASH "nociceptive" neuron. The molecular mechanisms of gating of TRPV4 in vivo need to be determined; in particular, whether TRPV4 in live animals is gated via phosphorylation of defined amino-acid residues or more directly through the osmotic stimulus itself.

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Year:  2005        PMID： 15952033     DOI： 10.1007/s00424-005-1449-8

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  33 in total

Review 1.  Sensory mechanisms in the behavioral control of body fluid balance: thirst and salt appetite.

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Journal:  Prog Psychobiol Physiol Psychol       Date:  1995

2.  Trp12, a novel Trp related protein from kidney.

Authors:  U Wissenbach; M Bödding; M Freichel; V Flockerzi
Journal:  FEBS Lett       Date:  2000-11-24       Impact factor: 4.124

Review 3.  Vertebrate and invertebrate TRPV-like mechanoreceptors.

Authors:  Hideki Mutai; Stefan Heller
Journal:  Cell Calcium       Date:  2003 May-Jun       Impact factor: 6.817

Review 4.  Ion channels and transporters involved in cell volume regulation and sensor mechanisms.

Authors:  Yasunobu Okada
Journal:  Cell Biochem Biophys       Date:  2004       Impact factor: 2.194

Review 5.  Cellular volume homeostasis.

Authors:  Kevin Strange
Journal:  Adv Physiol Educ       Date:  2004-12       Impact factor: 2.288

6.  OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans.

Authors:  H A Colbert; T L Smith; C I Bargmann
Journal:  J Neurosci       Date:  1997-11-01       Impact factor: 6.167

7.  An osmosensing signal transduction pathway in yeast.

Authors:  J L Brewster; T de Valoir; N D Dwyer; E Winter; M C Gustin
Journal:  Science       Date:  1993-03-19       Impact factor: 47.728

8.  Impaired osmotic sensation in mice lacking TRPV4.

Authors:  Atsuko Mizuno; Naoko Matsumoto; Masashi Imai; Makoto Suzuki
Journal:  Am J Physiol Cell Physiol       Date:  2003-07       Impact factor: 4.249

9.  Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons.

Authors:  Shenyuan Zhang; Irina Sokolchik; Gabriela Blanco; Ji Ying Sze
Journal:  Development       Date:  2004-03-03       Impact factor: 6.868

10.  Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4.

Authors:  J Vriens; H Watanabe; A Janssens; G Droogmans; T Voets; B Nilius
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-22       Impact factor: 11.205
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  19 in total

1.  Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice.

Authors:  Andrea L Clark; Bartholomew J Votta; Sanjay Kumar; Wolfgang Liedtke; Farshid Guilak
Journal:  Arthritis Rheum       Date:  2010-10

2.  Damage to lens fiber cells causes TRPV4-dependent Src family kinase activation in the epithelium.

Authors:  M Shahidullah; A Mandal; N A Delamere
Journal:  Exp Eye Res       Date:  2015-08-25       Impact factor: 3.467

Review 3.  Cells move when ions and water flow.

Authors:  Albrecht Schwab; Volodymyr Nechyporuk-Zloy; Anke Fabian; Christian Stock
Journal:  Pflugers Arch       Date:  2006-10-05       Impact factor: 3.657

4.  Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase.

Authors:  Silvia Sostegni; Alexei Diakov; Peter McIntyre; Nigel Bunnett; Christoph Korbmacher; Silke Haerteis
Journal:  Pflugers Arch       Date:  2014-06-08       Impact factor: 3.657

5.  When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor.

Authors:  Trine L Toft-Bertelsen; David Križaj; Nanna MacAulay
Journal:  J Physiol       Date:  2017-05-14       Impact factor: 5.182

6.  Calcium regulation by thermo- and osmosensing transient receptor potential vanilloid channels (TRPVs) in human conjunctival epithelial cells.

Authors:  Stefan Mergler; Fabian Garreis; Monika Sahlmüller; Ekaterini-Maria Lyras; Peter S Reinach; Abhilash Dwarakanath; Friedrich Paulsen; Uwe Pleyer
Journal:  Histochem Cell Biol       Date:  2012-02-12       Impact factor: 4.304

Review 7.  Fluid transport phenomena in ocular epithelia.

Authors:  Oscar A Candia; Lawrence J Alvarez
Journal:  Prog Retin Eye Res       Date:  2008-01-15       Impact factor: 21.198

8.  Altered central TRPV4 expression and lipid raft association related to inappropriate vasopressin secretion in cirrhotic rats.

Authors:  Flávia Regina Carreño; Lisa L Ji; J Thomas Cunningham
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2008-12-17       Impact factor: 3.619

Review 9.  Transient receptor potential vanilloid channels in hypertension, inflammation, and end organ damage: an imminent target of therapy for cardiovascular disease?

Authors:  Donna H Wang
Journal:  Curr Opin Cardiol       Date:  2008-07       Impact factor: 2.161

10.  Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel.

Authors:  Hitoshi Inada; Erik Procko; Marcos Sotomayor; Rachelle Gaudet
Journal:  Biochemistry       Date:  2012-07-25       Impact factor: 3.162
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