| Literature DB >> 15951823 |
Yvette Edghill-Smith1, Hana Golding, Jody Manischewitz, Lisa R King, Dorothy Scott, Mike Bray, Aysegul Nalca, Jay W Hooper, Chris A Whitehouse, Joern E Schmitz, Keith A Reimann, Genoveffa Franchini.
Abstract
Vaccination with live vaccinia virus affords long-lasting protection against variola virus, the agent of smallpox. Its mode of protection in humans, however, has not been clearly defined. Here we report that vaccinia-specific B-cell responses are essential for protection of macaques from monkeypox virus, a variola virus ortholog. Antibody-mediated depletion of B cells, but not CD4+ or CD8+ T cells, abrogated vaccine-induced protection from a lethal intravenous challenge with monkeypox virus. In addition, passive transfer of human vaccinia-neutralizing antibodies protected nonimmunized macaques from severe disease. Thus, vaccines able to induce long-lasting protective antibody responses may constitute realistic alternatives to the currently available smallpox vaccine (Dryvax).Entities:
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Year: 2005 PMID： 15951823 DOI： 10.1038/nm1261
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440