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Literature DB >> 15951531

Reinforcing the mucus: a new therapeutic approach for ulcerative colitis?

Abstract

Luminal delivery of phosphatidyl rich phospholipids appears to reduce mucosal inflammatory activity in a high proportion of patients with chronically active ulcerative colitis. The simplicity and apparent safety of this therapeutic approach offers new insights into the importance of the mucus barrier in the pathogenesis and treatment of ulcerative colitis.

Entities: Chemical Disease Species

Mesh：

Substances：
Phospholipids

Year: 2005 PMID： 15951531 PMCID： PMC1774597 DOI： 10.1136/gut.2004.058453

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

42 in total

Review 1. Pathogenic factors in inflammatory bowel disease. 2. Crohn's disease.

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Journal: Dig Dis Date: 1992 Impact factor: 2.404

2. Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis.

Authors: W Stremmel; U Merle; A Zahn; F Autschbach; U Hinz; R Ehehalt
Journal: Gut Date: 2005-07 Impact factor: 23.059

Review 3. Surface-active phospholipid: a Pandora's box of clinical applications. Part I. The lung and air spaces.

Authors: B A Hills
Journal: Intern Med J Date: 2002-04 Impact factor: 2.048

Review 4. Effect of lysophosphatidylcholine on transmembrane signal transduction.

Authors: N V Prokazova; N D Zvezdina; A A Korotaeva
Journal: Biochemistry (Mosc) Date: 1998-01 Impact factor: 2.487

5. Histochemical demonstration of desialation and desulphation of normal and inflammatory bowel disease rectal mucus by faecal extracts.

Authors: J M Rhodes; R R Black; R Gallimore; A Savage
Journal: Gut Date: 1985-12 Impact factor: 23.059

6. Direct evidence for phorbol ester-stimulated accumulation of diacylglycerol derived from phosphatidylcholine.

Authors: J A Glatz; J G Muir; A W Murray
Journal: Carcinogenesis Date: 1987-12 Impact factor: 4.944

7. Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidants.

Authors: Laurens Kruidenier; Ineke Kuiper; Cornelis B H W Lamers; Hein W Verspaget
Journal: J Pathol Date: 2003-09 Impact factor: 7.996

8. Interleukin 8 secretion by colonic crypt cells in vitro: response to injury suppressed by butyrate and enhanced in inflammatory bowel disease.

Authors: P Gibson; O Rosella
Journal: Gut Date: 1995-10 Impact factor: 23.059

9. Polyunsaturated phosphatidylcholine prevents stricture formation in a rat model of colitis.

Authors: M Mourelle; F Guarner; J R Malagelada
Journal: Gastroenterology Date: 1996-04 Impact factor: 22.682

10. Impaired sulphation of phenol by the colonic mucosa in quiescent and active ulcerative colitis.

Authors: B S Ramakrishna; I C Roberts-Thomson; P R Pannall; W E Roediger
Journal: Gut Date: 1991-01 Impact factor: 23.059

12 in total

Review 1. What is the origin of ulcerative colitis? Still more questions than answers.

Authors: Milan Lukas; Martin Bortlik; Zdenek Maratka
Journal: Postgrad Med J Date: 2006-10 Impact factor: 2.401

Review 2. Yogurt and Cardiometabolic Diseases: A Critical Review of Potential Mechanisms.

Authors: Melissa Anne Fernandez; Shirin Panahi; Noémie Daniel; Angelo Tremblay; André Marette
Journal: Adv Nutr Date: 2017-11-15 Impact factor: 8.701

3. Human intestinal MUC17 mucin augments intestinal cell restitution and enhances healing of experimental colitis.

Authors: Ying Luu; Wade Junker; Satyanarayana Rachagani; Srustidhar Das; Surinder K Batra; Robert L Heinrikson; Laurie L Shekels; Samuel B Ho
Journal: Int J Biochem Cell Biol Date: 2010-03-06 Impact factor: 5.085

Review 4. Helminthic therapy: improving mucosal barrier function.

Authors: Martin J Wolff; Mara J Broadhurst; P'ng Loke
Journal: Trends Parasitol Date: 2012-03-28

5. Muc17 protects intestinal epithelial cells from enteroinvasive E. coli infection by promoting epithelial barrier integrity.

Authors: Silvia Resta-Lenert; Srustidhar Das; Surinder K Batra; Samuel B Ho
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2011-03-10 Impact factor: 4.052

6. Impairment of mitochondrial acetoacetyl CoA thiolase activity in the colonic mucosa of patients with ulcerative colitis.

Authors: Srikanth Santhanam; Aparna Venkatraman; Balakrishnan S Ramakrishna
Journal: Gut Date: 2007-05-04 Impact factor: 23.059

7. Bio-physical characteristics of gastrointestinal mucosa of celiac patients: comparison with control subjects and effect of gluten free diet-.

Authors: Stefania Bertolazzi; Francesco Lanzarotto; Barbara Zanini; Chiara Ricci; Vincenzo Villanacci; Alberto Lanzini
Journal: BMC Gastroenterol Date: 2011-11-07 Impact factor: 3.067

8. Characterising the mucosal and systemic immune responses to experimental human hookworm infection.

Authors: Soraya Gaze; Henry J McSorley; James Daveson; Di Jones; Jeffrey M Bethony; Luciana M Oliveira; Richard Speare; James S McCarthy; Christian R Engwerda; John Croese; Alex Loukas
Journal: PLoS Pathog Date: 2012-02-09 Impact factor: 6.823

9. Short-term duodenal seal oil administration normalised n-6 to n-3 fatty acid ratio in rectal mucosa and ameliorated bodily pain in patients with inflammatory bowel disease.

Authors: Tormod Bjørkkjaer; Johan G Brun; Merete Valen; Gülen Arslan; Ragna Lind; Linn A Brunborg; Arnold Berstad; Livar Frøyland
Journal: Lipids Health Dis Date: 2006-03-20 Impact factor: 3.876

10. Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease.

Authors: Maaike Vancamelbeke; Tim Vanuytsel; Ricard Farré; Sare Verstockt; Marc Ferrante; Gert Van Assche; Paul Rutgeerts; Frans Schuit; Séverine Vermeire; Ingrid Arijs; Isabelle Cleynen
Journal: Inflamm Bowel Dis Date: 2017-10 Impact factor: 5.325