Relative efficacy of inactivated bovine herpesvirus-1 (BHV-1) vaccines.

The relative efficacy of four commercially available inactivated bovine herpesvirus-1 (BHV-1) vaccines was directly assessed in controlled studies in 5-6-month-old, BHV-1 naïve calves. The sero-response due to the basic course of two intramuscular vaccinations was closely similar for three of four vaccines whereas one vaccine did not induce seroconversion in five of six calves. At the level of challenge virus shedding in nasal mucus, all four vaccines were significantly protective but to a markedly variable degree. Clinically, however, the relative protection ranking of the vaccines was different to that observed for challenge virus shedding. There was no obvious correlation observed between pre-challenge circulating virus neutralising antibody titre and vaccine-induced protection against virus shedding or clinical signs following the intranasal BHV-1 challenge. Present comparative findings suggest that commercially available BHV-1 vaccines are likely to be of variable potency in the natural host.