| Literature DB >> 15950786 |
Johann Sellner1, Thorsten Lenhard, Jürgen Haas, Regina von Einsiedel, Uta Meyding-Lamadé.
Abstract
Glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) mRNA levels were studied in the course of murine herpes simplex virus encephalitis. Induction of GNDF and NT-3 (both P < 0.05) was found during acute encephalitis. Despite absence of clinical impairment, both neurotrophic factors were overexpressed 2 months (NT-3) and 6 months (GDNF) following infection (both P < 0.05). Neurotrophic factors play an important role in neuronal survival and recovery after acute injury to the central nervous system (CNS) and may represent an additional therapeutic target for treatment of viral encephalitis.Entities:
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Year: 2005 PMID： 15950786 DOI： 10.1016/j.molbrainres.2005.03.011
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X