Literature DB >> 15950472

Pyrrolo[1,2-a][1,4]benzodiazepine: a novel class of non-azole anti-dermatophyte anti-fungal agents.

Lieven Meerpoel1, Jef Van Gestel, Frans Van Gerven, Filip Woestenborghs, Patrick Marichal, Vic Sipido, Gilkerson Terence, Roger Nash, David Corens, Ray D Richards.   

Abstract

Broad screening revealed compound 1a to be a novel anti-fungal agent with high specificity towards dermatophytes. The anti-fungal structure-activity relationship of this novel class of 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepines is described together with its mode of action that appeared to be the inhibition of squalene epoxidase. Preliminary in vivo results of the most active compounds are also reported.

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Year:  2005        PMID： 15950472     DOI： 10.1016/j.bmcl.2005.05.007

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Synthesis of novel 7-aryl and 7-spiropyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine derivatives and their study as AChE inhibitors.

Authors:  Paola Acosta; Braulio Insuasty; Rodrigo Abonia; Margarita Gutierrez; Jairo Quiroga
Journal:  Mol Divers       Date:  2017-08-07       Impact factor: 2.943

2.  Driving Recursive Dehydration by PIII/PV Catalysis: Annulation of Amines and Carboxylic Acids by Sequential C-N and C-C Bond Formation.

Authors:  Morgan Lecomte; Jeffrey M Lipshultz; Shin-Ho Kim-Lee; Gen Li; Alexander T Radosevich
Journal:  J Am Chem Soc       Date:  2019-07-30       Impact factor: 15.419

Review 3.  Benzodiazepines: Drugs with Chemical Skeletons Suitable for the Preparation of Metallacycles with Potential Pharmacological Activity.

Authors:  Artur V da Silva; Simoni M P Meneghetti; Mario R Meneghetti
Journal:  Molecules       Date:  2021-05-10       Impact factor: 4.411
  3 in total

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