Literature DB >> 15950465

(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors.

Mark J Bamford1, Michael J Alberti, Nicholas Bailey, Susannah Davies, David K Dean, Alessandra Gaiba, Stephen Garland, John D Harling, David K Jung, Terence A Panchal, Christopher A Parr, Jon G Steadman, Andrew K Takle, James T Townsend, David M Wilson, Jason Witherington.   

Abstract

A novel series of imidazo[4,5-c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1.

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Year:  2005        PMID： 15950465     DOI： 10.1016/j.bmcl.2005.05.021

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors.

Authors:  Sheeba Varghese; Thulani Senanayake; Tracey Murray-Stewart; Kim Doering; Alison Fraser; Robert A Casero; Patrick M Woster
Journal:  J Med Chem       Date:  2008-03-19       Impact factor: 7.446

2.  High-throughput screening of a GlaxoSmithKline protein kinase inhibitor set identifies an inhibitor of human cytomegalovirus replication that prevents CREB and histone H3 post-translational modification.

Authors:  Amina S Khan; Matthew J Murray; Catherine M K Ho; William J Zuercher; Matthew B Reeves; Blair L Strang
Journal:  J Gen Virol       Date:  2017-04-20       Impact factor: 3.891

3.  N-{3-[2-(4-Fluoro-phen-oxy)eth-yl]-2,4-dioxo-1,3-diaza-spiro-[4.5]decan-7-yl}-4-methyl-benzamide.

Authors:  M Vinduvahini; Binoy Krishna Saha; H D Revanasiddappa; H C Devarajegowda
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-05-20

4.  N-{3-[2-(4-Fluoro-phen-oxy)eth-yl]-2,4-dioxo-1,3-diaza-spiro-[4.5]decan-7-yl}-4-meth-oxy-benzene-sulfonamide.

Authors:  M Vinduvahini; S Jeyaseelan; J Shylajakumari; H D Revanasiddappa; Venkatesh B Devaru
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-12-21

5.  N-[3-(4-Fluoro-benz-yl)-2,4-dioxo-1,3-diaza-spiro-[4.5]dec-8-yl]-2-methyl-benzene-sulfonamide.

Authors:  S Jeyaseelan; M Vinduvahini; M Madaiah; Suman Bhattacharya; H D Revanasiddappa
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-12-14

6.  The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design.

Authors:  Sylvain Couty; Isaac M Westwood; Andrew Kalusa; Celine Cano; Jon Travers; Kathy Boxall; Chiau Ling Chow; Sam Burns; Jessica Schmitt; Lisa Pickard; Caterina Barillari; P Craig McAndrew; Paul A Clarke; Spiros Linardopoulos; Roger J Griffin; G Wynne Aherne; Florence I Raynaud; Paul Workman; Keith Jones; Rob L M van Montfort
Journal:  Oncotarget       Date:  2013-10

Review 7.  Pharmacological Potential and Synthetic Approaches of Imidazo[4,5-b]pyridine and Imidazo[4,5-c]pyridine Derivatives.

Authors:  Malwina Krause; Henryk Foks; Katarzyna Gobis
Journal:  Molecules       Date:  2017-03-04       Impact factor: 4.411

8.  Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives and Analogs Targeting the NLRP3 Inflammasome.

Authors:  Liangkun Pan; Nan Hang; Chao Zhang; Yu Chen; Shuchun Li; Yang Sun; Zhongjun Li; Xiangbao Meng
Journal:  Molecules       Date:  2017-01-30       Impact factor: 4.411

9.  Functional annotation of chemical libraries across diverse biological processes.

Authors:  Jeff S Piotrowski; Sheena C Li; Raamesh Deshpande; Scott W Simpkins; Justin Nelson; Yoko Yashiroda; Jacqueline M Barber; Hamid Safizadeh; Erin Wilson; Hiroki Okada; Abraham A Gebre; Karen Kubo; Nikko P Torres; Marissa A LeBlanc; Kerry Andrusiak; Reika Okamoto; Mami Yoshimura; Eva DeRango-Adem; Jolanda van Leeuwen; Katsuhiko Shirahige; Anastasia Baryshnikova; Grant W Brown; Hiroyuki Hirano; Michael Costanzo; Brenda Andrews; Yoshikazu Ohya; Hiroyuki Osada; Minoru Yoshida; Chad L Myers; Charles Boone
Journal:  Nat Chem Biol       Date:  2017-07-24       Impact factor: 15.040

10.  The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation.

Authors:  Ugo Moens; Sergiy Kostenko; Baldur Sveinbjørnsson
Journal:  Genes (Basel)       Date:  2013-03-26       Impact factor: 4.096
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