| Literature DB >> 15950464 |
Hiroo Koyama1, Julia K Boueres, Daniel J Miller, Joel P Berger, Karen L MacNaul, Pei-ran Wang, Marc C Ippolito, Samuel D Wright, Arun K Agrawal, David E Moller, Soumya P Sahoo.
Abstract
A SAR study was conducted on chromane-2-carboxylic acid toward selective PPARalpha agonisim. As a result, highly potent, and selective PPARalpha agonists were discovered. The optimized compound 43 exhibited robust lowering of total cholesterol levels in hamster and dog animal models.Entities:
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Year: 2005 PMID： 15950464 DOI： 10.1016/j.bmcl.2005.05.028
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823