| Literature DB >> 15949850 |
Roberto Furlan1, Marco Rovaris, Filippo Martinelli Boneschi, Mohsen Khademi, Alessandra Bergami, Maira Gironi, Michela Deleidi, Federica Agosta, Diego Franciotta, Elio Scarpini, Antonio Uccelli, Mauro Zaffaroni, Asli Kurne, Giancarlo Comi, Tomas Olsson, Massimo Filippi, Gianvito Martino.
Abstract
Reliable, and easy to measure, immunological markers able to denote disease characteristics in multiple sclerosis (MS) patients are still lacking. We applied a multivariate statistical analysis on results obtained by measuring-by real-time RT-PCR-mRNA levels of 25 immunological relevant molecules in PBMCs from 198 MS patients. The combined measurement of mRNA levels of IL-1beta, TNF-alpha, TGF-beta, CCL20 and CCR3 was able to distinguish MS patients from healthy individuals. CXCR5, CCL5, and CCR3 combined mRNA levels identify primary progressive MS patients while TNF-alpha, IL-10, CXCL10 and CCR3 differentiate relapsing MS patients. Our results indicate that multi-parametric analysis of mRNA levels of immunological relevant molecules in PBMCs may represent a successful strategy for the identification of putative peripheral markers of disease state and disease activity in MS patients.Entities:
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Year: 2005 PMID： 15949850 DOI： 10.1016/j.jneuroim.2005.04.012
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478