Literature DB >> 15949493

The relation between MRI measures of inflammation and neurodegeneration in multiple sclerosis.

Matilde Inglese1, Beatrice Benedetti, Massimo Filippi.   

Abstract

Gadolinium-enhanced magnetic resonance imaging (MRI) and measures of brain volume have been extensively applied in large-scale studies to assess disease activity and irreversible tissue damage in multiple sclerosis (MS). Although histopathological studies of MS demonstrated that axonal transection occurs at sites of inflammatory changes, the correlation between brain tissue loss and gadolinium enhancement was found to be either absent or poor in virtually all in vivo MRI studies. This review discusses the reasons of this "inflammation/neurodegeneration mismatch" in MS and proposes possible strategies for a better in vivo characterization of the complex pathological process of this disease.

Entities:  

Mesh：

Year:  2005        PMID： 15949493     DOI： 10.1016/j.jns.2005.03.001

Source DB:  PubMed          Journal:  J Neurol Sci        ISSN： 0022-510X            Impact factor:   3.181


  6 in total

1.  Rostrocaudal analysis of corpus callosum demyelination and axon damage across disease stages refines diffusion tensor imaging correlations with pathological features.

Authors:  Mingqiang Xie; Jennifer E Tobin; Matthew D Budde; Chin-I Chen; Kathryn Trinkaus; Anne H Cross; Dennis P McDaniel; Sheng-Kwei Song; Regina C Armstrong
Journal:  J Neuropathol Exp Neurol       Date:  2010-07       Impact factor: 3.685

2.  Normal appearing white matter permeability: a marker of inflammation and information processing speed deficit among relapsing remitting multiple sclerosis patients.

Authors:  Eldar Eftekhari; Seyed-Parsa Hojjat; Rita Vitorino; Timothy J Carroll; Charles Grady Cantrell; Liesly Lee; Matthew W Taylor; Sarah A Morrow; Haddas Benhabib; Richard I Aviv; Andrea Kassner
Journal:  Neuroradiology       Date:  2017-06-16       Impact factor: 2.804

Review 3.  MRI evidence for multiple sclerosis as a diffuse disease of the central nervous system.

Authors:  Massimo Filippi; Maria Assunta Rocca
Journal:  J Neurol       Date:  2005-11       Impact factor: 4.849

4.  A three-year study of brain atrophy after autologous hematopoietic stem cell transplantation in rapidly evolving secondary progressive multiple sclerosis.

Authors:  M A Rocca; T Mondria; P Valsasina; M P Sormani; Z H Flach; P A Te Boekhorst; G Comi; R Q Hintzen; M Filippi
Journal:  AJNR Am J Neuroradiol       Date:  2007-09-20       Impact factor: 3.825

5.  Smoking is associated with progressive disease course and increased progression in clinical disability in a prospective cohort of people with multiple sclerosis.

Authors:  Fotini Pittas; Anne-Louise Ponsonby; Ingrid A F van der Mei; Bruce V Taylor; Leigh Blizzard; Patricia Groom; Obioha C Ukoumunne; Terry Dwyer
Journal:  J Neurol       Date:  2009-04-09       Impact factor: 4.849

Review 6.  The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: A systematic review and meta-analysis.

Authors:  Daisy Mollison; Robin Sellar; Mark Bastin; Denis Mollison; Siddharthan Chandran; Joanna Wardlaw; Peter Connick
Journal:  PLoS One       Date:  2017-05-15       Impact factor: 3.240
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.