| Literature DB >> 15947927 |
Pravas Mishra1, H P Pati, Tathagat Chatterjee, Ashish Dixit, Dharma R Choudhary, M Upendra Srinivas, Manoranjan Mahapatra, V P Choudhry.
Abstract
Hb S and Hb E are globally common hemoglobinopathies. However, Hb SE double heterozygous state is uncommon, with only 25 cases reported so far in literature. We present two more cases. One presented with gallstones, and the other was asymptomatic. This type of disorder was previously described as a relatively asymptomatic condition compared to HbSS. A review of the 25 reported cases in literature shows that 40.7% (11/27) of these cases are symptomatic. Gender, hematological parameters and levels of Hb S, E or F do not predict clinical severity.Entities:
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Year: 2005 PMID： 15947927 DOI： 10.1007/s00277-005-1044-2
Source DB: PubMed Journal: Ann Hematol ISSN： 0939-5555 Impact factor: 3.673