BACKGROUND: Little is known about the influence of high exposure to bisphenol A on recurrent miscarriage and immunoendocrine abnormalities. METHODS: Serum bisphenol A, antiphospholipid antibodies (aPLs), antinuclear antibodies (ANAs), natural killer cell (NK) activity, prolactin, progesterone, thyroid-stimulating hormone (TSH) and free T4 were examined in 45 patients with a history of three or more (3-11) consecutive first-trimester miscarriages and 32 healthy women with no history of live birth and infertility. Subsequent pregnancy outcome and embryonic karyotype of abortuses were examined prospectively. RESULTS: The mean+/-SD values for bisphenol A in patients were 2.59+/-5.23 ng/ml, significantly higher than the 0.77+/-0.38 ng/ml found for control women (P=0.024). High exposure to bisphenol A was associated with the presence of ANAs but not hypothyroidism, hyperprolactinaemia, luteal phase defects, NK cell activity or aPLs. A high level of bisphenol A in itself did not predict subsequent miscarriage. CONCLUSION: Exposure to bisphenol A is associated with recurrent miscarriage.
BACKGROUND: Little is known about the influence of high exposure to bisphenol A on recurrent miscarriage and immunoendocrine abnormalities. METHODS: Serum bisphenol A, antiphospholipid antibodies (aPLs), antinuclear antibodies (ANAs), natural killer cell (NK) activity, prolactin, progesterone, thyroid-stimulating hormone (TSH) and free T4 were examined in 45 patients with a history of three or more (3-11) consecutive first-trimester miscarriages and 32 healthy women with no history of live birth and infertility. Subsequent pregnancy outcome and embryonic karyotype of abortuses were examined prospectively. RESULTS: The mean+/-SD values for bisphenol A in patients were 2.59+/-5.23 ng/ml, significantly higher than the 0.77+/-0.38 ng/ml found for control women (P=0.024). High exposure to bisphenol A was associated with the presence of ANAs but not hypothyroidism, hyperprolactinaemia, luteal phase defects, NK cell activity or aPLs. A high level of bisphenol A in itself did not predict subsequent miscarriage. CONCLUSION: Exposure to bisphenol A is associated with recurrent miscarriage.
Authors: Carmen Messerlian; Paige L Williams; Lidia Mínguez-Alarcón; Courtney C Carignan; Jennifer B Ford; Craig M Butt; John D Meeker; Heather M Stapleton; Irene Souter; Russ Hauser Journal: Fertil Steril Date: 2018-11 Impact factor: 7.329
Authors: Laura N Vandenberg; Maricel V Maffini; Carlos Sonnenschein; Beverly S Rubin; Ana M Soto Journal: Endocr Rev Date: 2008-12-12 Impact factor: 19.871
Authors: Jung H Kim; Maureen A Sartor; Laura S Rozek; Christopher Faulk; Olivia S Anderson; Tamara R Jones; Muna S Nahar; Dana C Dolinoy Journal: BMC Genomics Date: 2014-01-17 Impact factor: 3.969
Authors: David Cantonwine; John D Meeker; Howard Hu; Brisa N Sánchez; Héctor Lamadrid-Figueroa; Adriana Mercado-García; Gamola Z Fortenberry; Antonia M Calafat; Martha Maria Téllez-Rojo Journal: Environ Health Date: 2010-10-18 Impact factor: 5.984