| Literature DB >> 15946842 |
Carmen E Burgos-Lepley1, Lisa R Thompson, Clare O Kneen, Simon A Osborne, Justin S Bryans, Thomas Capiris, Nirmala Suman-Chauhan, David J Dooley, Cindy M Donovan, Mark J Field, Mark G Vartanian, Jack J Kinsora, Susan M Lotarski, Ayman El-Kattan, Karen Walters, Madhu Cherukury, Charles P Taylor, David J Wustrow, Jacob B Schwarz.
Abstract
A series of carboxylate bioisosteres of structures related to gabapentin 1 have been prepared. When the carboxylate was replaced by a tetrazole, this group was recognized by the alpha2-delta protein. Further characterization of alpha2-delta binding compounds 14a and 14b revealed a similar pattern of functional in vitro and in vivo activity to gabapentin 1.Entities:
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Year: 2005 PMID： 15946842 DOI： 10.1016/j.bmcl.2005.05.016
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823