| Literature DB >> 15946811 |
Subbu S Venkatraman1, Pan Jie, Feng Min, Boey Yin Chiang Freddy, Gan Leong-Huat.
Abstract
Triblock copolymer PLA-PEG-PLA were synthesized using ring opening polymerization with different LA/EG ratio. Micellar aggregates were prepared from these block copolymers and characterized. The degradation characteristics of selected copolymers were assessed in both micellar and film forms. Surface segregation of PEG was also quantified as a function of copolymer composition. Anti-cancer drugs 5-FU and paclitaxel were loaded into the micellar nanospheres with good efficiency. The drug release profile showed good control over the release of paclitaxel from these polymers.Entities:
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Year: 2005 PMID： 15946811 DOI： 10.1016/j.ijpharm.2005.03.023
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875