PURPOSE: The goal of the present study was to investigate the relationship between sleep, hypothalamic pathology, and seizures in spontaneous epileptic rats. METHODS: Rats were implanted with radiotelemetry transmitters for measuring electrocorticogram (ECoG) and stimulation electrodes in the hippocampus. Epileptogenesis was triggered by 2 h of electical stimulation-induced self-sustained status epilepticus (SSSE). After SSSE, ECoGs were monitored over a 15-week period for the occurrence of interictal high-amplitude low-frequency (HALF) acitvity and spontaneous reoccurring seizures (SRSs). RESULTS: Spontaneous epileptic rats showed clinical features of temporal lobe epilepsy (TLE), such as spontaneous seizures, interictal activity and neuronal cell loss in the dorsomedial hypothalamus, a region important for normal sleep regulation. Interestingly, epileptic rats showed disturbances in sleep architecture, with a high percentage of the seizures occurring during sleep. CONCLUSIONS: Therefore we conclude that a close association exists between epileptiform activity and alterations in sleep architecture that may be related to hypothalamic pathology.
PURPOSE: The goal of the present study was to investigate the relationship between sleep, hypothalamic pathology, and seizures in spontaneous epilepticrats. METHODS:Rats were implanted with radiotelemetry transmitters for measuring electrocorticogram (ECoG) and stimulation electrodes in the hippocampus. Epileptogenesis was triggered by 2 h of electical stimulation-induced self-sustained status epilepticus (SSSE). After SSSE, ECoGs were monitored over a 15-week period for the occurrence of interictal high-amplitude low-frequency (HALF) acitvity and spontaneous reoccurring seizures (SRSs). RESULTS: Spontaneous epilepticrats showed clinical features of temporal lobe epilepsy (TLE), such as spontaneous seizures, interictal activity and neuronal cell loss in the dorsomedial hypothalamus, a region important for normal sleep regulation. Interestingly, epilepticrats showed disturbances in sleep architecture, with a high percentage of the seizures occurring during sleep. CONCLUSIONS: Therefore we conclude that a close association exists between epileptiform activity and alterations in sleep architecture that may be related to hypothalamic pathology.
Authors: Kristina A Fenoglio-Simeone; Julianne C Wilke; Heather L Milligan; Charles N Allen; Jong M Rho; Rama K Maganti Journal: Epilepsia Date: 2009-06-01 Impact factor: 5.864
Authors: David A Stanley; Sachin S Talathi; Mansi B Parekh; Daniel J Cordiner; Junli Zhou; Thomas H Mareci; William L Ditto; Paul R Carney Journal: J Neurophysiol Date: 2013-05-15 Impact factor: 2.714