Literature DB >> 1594586

Determination by systematic deletion of the amino acids essential for catalysis by ricin A chain.

K N Morris1, I G Wool.   

Abstract

The A chain of ricin is a RNA N-glycosidase that inactivates ribosomes by depurination of a single adenosine in 28S rRNA. Of the 267 amino acids in the protein, 222 (83%) could be deleted from one or another of 74 mutants without loss of the capacity of the protein to recognize a single nucleotide from among the 7000 in ribosomes or to catalyze hydrolysis.

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Year:  1992        PMID： 1594586      PMCID： PMC49189          DOI： 10.1073/pnas.89.11.4869

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  37 in total

1.  The role of internal packing interactions in determining the structure and stability of a protein.

Authors:  W A Lim; R T Sauer
Journal:  J Mol Biol       Date:  1991-05-20       Impact factor: 5.469

2.  A method to identify protein sequences that fold into a known three-dimensional structure.

Authors:  J U Bowie; R Lüthy; D Eisenberg
Journal:  Science       Date:  1991-07-12       Impact factor: 47.728

3.  Crystallographic refinement of ricin to 2.5 A.

Authors:  E Rutenber; B J Katzin; S Ernst; E J Collins; D Mlsna; M P Ready; J D Robertus
Journal:  Proteins       Date:  1991

4.  Introduction of guest peptides into Escherichia coli alkaline phosphatase. Excision and purification of a dynorphin analogue from an active chimeric protein.

Authors:  P I Freimuth; J W Taylor; E T Kaiser
Journal:  J Biol Chem       Date:  1990-01-15       Impact factor: 5.157

Review 5.  Areas, volumes, packing and protein structure.

Authors:  F M Richards
Journal:  Annu Rev Biophys Bioeng       Date:  1977

6.  Two-codon insertion mutagenesis of plasmid genes by using single-stranded hexameric oligonucleotides.

Authors:  F Barany
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

7.  Nucleotide sequence of cloned cDNA coding for preproricin.

Authors:  F I Lamb; L M Roberts; J M Lord
Journal:  Eur J Biochem       Date:  1985-04-15

8.  Site-directed mutagenesis of ricin A chain Trp 211 to Phe.

Authors:  J L Bradley; P M McGuire
Journal:  Int J Pept Protein Res       Date:  1990-04

9.  Structure of ricin A-chain at 2.5 A.

Authors:  B J Katzin; E J Collins; J D Robertus
Journal:  Proteins       Date:  1991

10.  The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

Authors:  Y Endo; K Mitsui; M Motizuki; K Tsurugi
Journal:  J Biol Chem       Date:  1987-04-25       Impact factor: 5.157
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  12 in total

1.  Structural insights into the neutralization mechanism of monoclonal antibody 6C2 against ricin.

Authors:  Yuwei Zhu; Jianxin Dai; Tiancheng Zhang; Xu Li; Pengfei Fang; Huajing Wang; Yongliang Jiang; Xiaojie Yu; Tian Xia; Liwen Niu; Yajun Guo; Maikun Teng
Journal:  J Biol Chem       Date:  2013-07-12       Impact factor: 5.157

2.  Identification of a novel functional domain of ricin responsible for its potent toxicity.

Authors:  Jianxing Dai; Lei Zhao; Haiou Yang; Huaizu Guo; Kexing Fan; Huaqing Wang; Weizhu Qian; Dapeng Zhang; Bohua Li; Hao Wang; Yajun Guo
Journal:  J Biol Chem       Date:  2011-02-08       Impact factor: 5.157

3.  High-resolution NMR study of a synthetic oligoribonucleotide with a tetranucleotide GAGA loop that is a substrate for the cytotoxic protein, ricin.

Authors:  M Orita; F Nishikawa; T Shimayama; K Taira; Y Endo; S Nishikawa
Journal:  Nucleic Acids Res       Date:  1993-12-11       Impact factor: 16.971

4.  Analysis of the contribution of an amphiphilic alpha-helix to the structure and to the function of ricin A chain.

Authors:  K N Morris; I G Wool
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-02       Impact factor: 11.205

5.  Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalk.

Authors:  Xiao-Ping Li; Peter C Kahn; Jennifer Nielsen Kahn; Przemyslaw Grela; Nilgun E Tumer
Journal:  J Biol Chem       Date:  2013-09-03       Impact factor: 5.157

6.  Ribosome depurination is not sufficient for ricin-mediated cell death in Saccharomyces cerevisiae.

Authors:  Xiao-Ping Li; Marianne Baricevic; Hemalatha Saidasan; Nilgun E Tumer
Journal:  Infect Immun       Date:  2006-11-13       Impact factor: 3.441

7.  A relatively low level of ribosome depurination by mutant forms of ricin toxin A chain can trigger protein synthesis inhibition, cell signaling and apoptosis in mammalian cells.

Authors:  Amanda E Jetzt; Ju-Shun Cheng; Xiao-Ping Li; Nilgun E Tumer; Wendie S Cohick
Journal:  Int J Biochem Cell Biol       Date:  2012-09-12       Impact factor: 5.085

8.  Generation of pokeweed antiviral protein mutations in Saccharomyces cerevisiae: evidence that ribosome depurination is not sufficient for cytotoxicity.

Authors:  Katalin A Hudak; Bijal A Parikh; Rong Di; Marianne Baricevic; Maria Santana; Mirjana Seskar; Nilgun E Tumer
Journal:  Nucleic Acids Res       Date:  2004-08-10       Impact factor: 16.971

9.  A translational fidelity mutation in the universally conserved sarcin/ricin domain of 25S yeast ribosomal RNA.

Authors:  R Liu; S W Liebman
Journal:  RNA       Date:  1996-03       Impact factor: 4.942

10.  High-resolution NMR study of a GdAGA tetranucleotide loop that is an improved substrate for ricin, a cytotoxic plant protein.

Authors:  M Orita; F Nishikawa; T Kohno; T Senda; Y Mitsui; E Yaeta; T Kazunari; S Nishikawa
Journal:  Nucleic Acids Res       Date:  1996-02-15       Impact factor: 16.971
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