Literature DB >> 15945406

Animal surgery during spaceflight on the Neurolab Shuttle mission.

Mark R Campbell1, David R Williams, Jay C Buckey, Andrew W Kirkpatrick.   

Abstract

INTRODUCTION: A surgical procedure has never been required or performed on a human in space. Parabolic microgravity simulations have suggested that surgery would be technically feasible during spaceflight. PROCEDURES: Survival surgery was performed for the first time on rats during the STS-90 Neurolab Shuttle mission. Craniotomy, leg dissection, thoracotomy, laminectomy, and laparotomy were performed as a part of physiological investigations.
RESULTS: Surgical techniques successfully demonstrated in rats during spaceflight included general anesthesia, wound closure, wound healing, hemostasis, control of surgical fluids, operator restraint, and control of surgical instruments. No decrement in manual dexterity was noted by the crew, although operative time was longer compared with ground experience due to the need to maintain restraint of surgical supplies and instruments.
CONCLUSIONS: The demonstration that technically demanding dissections could be accomplished successfully in space on rats suggests that comparable complex surgical procedures should be feasible on humans, if necessary, on future long-duration missions.

Entities:  

Keywords:  NASA Discipline Clinical Medicine; Non-NASA Center

Mesh:

Year:  2005        PMID: 15945406

Source DB:  PubMed          Journal:  Aviat Space Environ Med        ISSN: 0095-6562


  9 in total

1.  Surgery in Space: Where are we at now?

Authors:  Laura Drudi; Chad G Ball; Andrew W Kirkpatrick; Joan Saary; S Marlene Grenon
Journal:  Acta Astronaut       Date:  2012       Impact factor: 2.413

2.  Technical innovations that may facilitate real-time telementoring of damage control surgery in austere environments: a proof of concept comparative evaluation of the importance of surgical experience, telepresence, gravity and mentoring in the conduct of damage control laparotomies.

Authors:  Andrew W Kirkpatrick; Anthony LaPorta; Susan Brien; Tim Leslie; Elon Glassberg; Jessica McKee; Chad G Ball; Heather E Wright Beatty; Jocelyn Keillor; Derek J Roberts; Homer Tien
Journal:  Can J Surg       Date:  2015-06       Impact factor: 2.089

3.  Mars ain't the kind of place to raise your kid: ethical implications of pregnancy on missions to colonize other planets.

Authors:  Haley Schuster; Steven L Peck
Journal:  Life Sci Soc Policy       Date:  2016-08-25

4.  Preparation of A Spaceflight: Apoptosis Search in Sutured Wound Healing Models.

Authors:  Stefan Riwaldt; Monica Monici; Asbjørn Graver Petersen; Uffe Birk Jensen; Katja Evert; Desiré Pantalone; Kirsten Utpatel; Matthias Evert; Markus Wehland; Marcus Krüger; Sascha Kopp; Sofie Frandsen; Thomas Corydon; Jayashree Sahana; Johann Bauer; Ronald Lützenberg; Manfred Infanger; Daniela Grimm
Journal:  Int J Mol Sci       Date:  2017-12-03       Impact factor: 5.923

5.  Effect of Unloading Condition on the Healing Process and Effectiveness of Platelet Rich Plasma as a Countermeasure: Study on In Vivo and In Vitro Wound Healing Models.

Authors:  Francesca Cialdai; Alessandra Colciago; Desiré Pantalone; Angela Maria Rizzo; Stefania Zava; Lucia Morbidelli; Fabio Celotti; Daniele Bani; Monica Monici
Journal:  Int J Mol Sci       Date:  2020-01-09       Impact factor: 5.923

6.  The Effects of Long Duration Spaceflight on Sensorimotor Control and Cognition.

Authors:  Grant D Tays; Kathleen E Hupfeld; Heather R McGregor; Ana Paula Salazar; Yiri Eleana De Dios; Nichole E Beltran; Patricia A Reuter-Lorenz; Igor S Kofman; Scott J Wood; Jacob J Bloomberg; Ajitkumar P Mulavara; Rachael D Seidler
Journal:  Front Neural Circuits       Date:  2021-10-26       Impact factor: 3.492

Review 7.  Role of fibroblasts in wound healing and tissue remodeling on Earth and in space.

Authors:  Francesca Cialdai; Chiara Risaliti; Monica Monici
Journal:  Front Bioeng Biotechnol       Date:  2022-10-04

8.  Severe traumatic injury during long duration spaceflight: Light years beyond ATLS.

Authors:  Andrew W Kirkpatrick; Chad G Ball; Mark Campbell; David R Williams; Scott E Parazynski; Kenneth L Mattox; Timothy J Broderick
Journal:  J Trauma Manag Outcomes       Date:  2009-03-25

Review 9.  Individual predictors of sensorimotor adaptability.

Authors:  Rachael D Seidler; Ajitkumar P Mulavara; Jacob J Bloomberg; Brian T Peters
Journal:  Front Syst Neurosci       Date:  2015-07-06
  9 in total

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