Literature DB >> 15944308

Phosphatidylinositol-specific phospholipase C of Bacillus anthracis down-modulates the immune response.

Lauren A Zenewicz1, Zhengyu Wei, Howard Goldfine, Hao Shen.   

Abstract

Phosphatidylinositol-specific phospholipases (PI-PLCs) are virulence factors produced by many pathogenic bacteria, including Bacillus anthracis and Listeria monocytogenes. Bacillus PI-PLC differs from Listeria PI-PLC in that it has strong activity for cleaving GPI-anchored proteins. Treatment of murine DCs with Bacillus, but not Listeria, PI-PLC inhibited dendritic cell (DC) activation by TLR ligands. Infection of mice with Listeria expressing B. anthracis PI-PLC resulted in a reduced Ag-specific CD4 T cell response. These data indicate that B. anthracis PI-PLC down-modulates DC function and T cell responses, possibly by cleaving GPI-anchored proteins important for TLR-mediated DC activation.

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Year:  2005        PMID： 15944308     DOI： 10.4049/jimmunol.174.12.8011

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  10 in total

1.  Bacillus anthracis phospholipases C facilitate macrophage-associated growth and contribute to virulence in a murine model of inhalation anthrax.

Authors:  Brian J Heffernan; Brendan Thomason; Amy Herring-Palmer; Lee Shaughnessy; Rod McDonald; Nathan Fisher; Gary B Huffnagle; Philip Hanna
Journal:  Infect Immun       Date:  2006-07       Impact factor: 3.441

2.  Phosphatidylinositol-specific phospholipase C contributes to survival of Staphylococcus aureus USA300 in human blood and neutrophils.

Authors:  Mark J White; Jeffrey M Boyd; Alexander R Horswill; William M Nauseef
Journal:  Infect Immun       Date:  2014-01-22       Impact factor: 3.441

Review 3.  Bacterial Sphingomyelinases and Phospholipases as Virulence Factors.

Authors:  Marietta Flores-Díaz; Laura Monturiol-Gross; Claire Naylor; Alberto Alape-Girón; Antje Flieger
Journal:  Microbiol Mol Biol Rev       Date:  2016-06-15       Impact factor: 11.056

4.  The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.

Authors:  Matthew T G Holden; Helena M B Seth-Smith; Lisa C Crossman; Mohammed Sebaihia; Stephen D Bentley; Ana M Cerdeño-Tárraga; Nicholas R Thomson; Nathalie Bason; Michael A Quail; Sarah Sharp; Inna Cherevach; Carol Churcher; Ian Goodhead; Heidi Hauser; Nancy Holroyd; Karen Mungall; Paul Scott; Danielle Walker; Brian White; Helen Rose; Pernille Iversen; Dalila Mil-Homens; Eduardo P C Rocha; Arsenio M Fialho; Adam Baldwin; Christopher Dowson; Bart G Barrell; John R Govan; Peter Vandamme; C Anthony Hart; Eshwar Mahenthiralingam; Julian Parkhill
Journal:  J Bacteriol       Date:  2008-10-17       Impact factor: 3.490

5.  Correlation of vesicle binding and phospholipid dynamics with phospholipase C activity: insights into phosphatidylcholine activation and surface dilution inhibition.

Authors:  Mingming Pu; Xiaomin Fang; Alfred G Redfield; Anne Gershenson; Mary F Roberts
Journal:  J Biol Chem       Date:  2009-03-31       Impact factor: 5.157

6.  Quantifying transient interactions between Bacillus phosphatidylinositol-specific phospholipase-C and phosphatidylcholine-rich vesicles.

Authors:  Boqian Yang; Mingming Pu; Hanif M Khan; Larry Friedman; Nathalie Reuter; Mary F Roberts; Anne Gershenson
Journal:  J Am Chem Soc       Date:  2014-12-23       Impact factor: 15.419

7.  In silico identification and characterization of a hypothetical protein of Mycobacterium tuberculosis EAI5 as a potential virulent factor.

Authors:  Debdoot Gupta; Samiddha Banerjee; Santanu Pailan; Pradipta Saha
Journal:  Bioinformation       Date:  2016-06-15

Review 8.  Categorizing Sequences of Concern by Function To Better Assess Mechanisms of Microbial Pathogenesis.

Authors:  Todd J Treangen; Krista L Ternus; Gene D Godbold; Anthony D Kappell; Danielle S LeSassier
Journal:  Infect Immun       Date:  2021-11-15       Impact factor: 3.609

Review 9.  Phosphatidylcholine Cation-Tyrosine π Complexes: Motifs for Membrane Binding by a Bacterial Phospholipase C.

Authors:  Mary F Roberts; Anne Gershenson; Nathalie Reuter
Journal:  Molecules       Date:  2022-09-21       Impact factor: 4.927

10.  Phosphatidylinositol-specific phospholipase C enhances epidermal penetration by Staphylococcus aureus.

Authors:  Yoshikazu Nakamura; Kaori Kanemaru; Madoka Shoji; Kengo Totoki; Karen Nakamura; Hidemasa Nakaminami; Keisuke Nakase; Norihisa Noguchi; Kiyoko Fukami
Journal:  Sci Rep       Date:  2020-10-20       Impact factor: 4.379
  10 in total

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