Literature DB >> 15943574

New two-amino acid insertion near codon 70 of the HIV type 1 protease gene.

Mark A Winters1, Ron M Kagan, Peter N R Heseltine, Thomas C Merigan.   

Abstract

A two-amino acid insertion near codon 70 of the HIV-1 protease gene was found in an individual failing protease inhibitor therapy. Susceptibility of this strain to protease inhibitors was similar to that of non-insert-containing strains with comparable resistance mutations and one or more other major PI mutations.

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Year:  2005        PMID： 15943574     DOI： 10.1089/aid.2005.21.311

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN： 0889-2229            Impact factor:   2.205


  3 in total

Review 1.  Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: clinical impact and molecular mechanisms.

Authors:  Mark A Winters; Thomas C Merigan
Journal:  Antimicrob Agents Chemother       Date:  2005-07       Impact factor: 5.191

2.  Novel codon insert in HIV type 1 clade B reverse transcriptase associated with low-level viremia during antiretroviral therapy.

Authors:  Antoine Chaillon; Sara Gianella; Homero Vazquez; Caroline Ignacio; Adam C Zweig; Douglas D Richman; Davey M Smith
Journal:  AIDS Res Hum Retroviruses       Date:  2013-10-05       Impact factor: 2.205

3.  Functional correlation between a novel amino acid insertion at codon 19 in the protease of human immunodeficiency virus type 1 and polymorphism in the p1/p6 Gag cleavage site in drug resistance and replication fitness.

Authors:  Terrence W Brann; Robin L Dewar; Min-Kan Jiang; Akram Shah; Kunio Nagashima; Julia A Metcalf; Judith Falloon; H Clifford Lane; Tomozumi Imamichi
Journal:  J Virol       Date:  2006-06       Impact factor: 5.103
  3 in total

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