Literature DB >> 15942906

Protective effect of the HLA-Bw4I80 epitope and the killer cell immunoglobulin-like receptor 3DS1 gene against the development of hepatocellular carcinoma in patients with hepatitis C virus infection.

Antonio López-Vázquez1, Luis Rodrigo, Jesus Martínez-Borra, Ramón Pérez, Manuel Rodríguez, Juan L Fdez-Morera, Dolores Fuentes, Sandra Rodríguez-Rodero, Segundo Gonzáez, Carlos López-Larrea.   

Abstract

The aim of the present study was to investigate, in 152 Spanish patients infected with hepatitis C virus (HCV), the possibility that killer cell immunoglobulin-like receptors (KIRs) influence progression to hepatocellular carcinoma. KIRs are related to the activation and inhibition of natural killer cells and may play an important role in the innate response against infection with such viruses as HCV. We found that the human leukocyte antigen-Bw4I80 epitope and the KIR3DS1 gene were more frequent in HCV carriers than in patients with hepatocellular carcinoma. Moreover, these associations were not independent of each other--the KIR3DS1/Bw4I80 genotype clearly was also more frequent in HCV carriers (odds ratio, 24.22).

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Year:  2005        PMID： 15942906     DOI： 10.1086/430351

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  51 in total

1.  The potential influence of KIR cluster profiles on disease patterns of Canadian Aboriginals and other indigenous peoples of the Americas.

Authors:  Julia D Rempel; Kim Hawkins; Erin Lande; Peter Nickerson
Journal:  Eur J Hum Genet       Date:  2011-07-06       Impact factor: 4.246

2.  The relation of HLA genotype to hepatitis C viral load and markers of liver fibrosis in HIV-infected and HIV-uninfected women.

Authors:  Mark H Kuniholm; Xiaojiang Gao; Xiaonan Xue; Andrea Kovacs; Darlene Marti; Chloe L Thio; Marion G Peters; Ruth M Greenblatt; James J Goedert; Mardge H Cohen; Howard Minkoff; Stephen J Gange; Kathryn Anastos; Melissa Fazzari; Mary A Young; Howard D Strickler; Mary Carrington
Journal:  J Infect Dis       Date:  2011-06-15       Impact factor: 5.226

Review 3.  Interaction of NK inhibitory receptor genes with HLA-C and MHC class II alleles in Hepatitis C virus infection outcome.

Authors:  Viviana Romero; Jose Azocar; Joaquin Zúñiga; Olga P Clavijo; Daniel Terreros; Xiangjun Gu; Zaheed Husain; Raymond T Chung; Christopher Amos; Edmond J Yunis
Journal:  Mol Immunol       Date:  2008-03-04       Impact factor: 4.407

4.  Skin Cancer Risk Is Modified by KIR/HLA Interactions That Influence the Activation of Natural Killer Immune Cells.

Authors:  Karin A Vineretsky; Margaret R Karagas; Brock C Christensen; Jacquelyn K Kuriger-Laber; Ann E Perry; Craig A Storm; Heather H Nelson
Journal:  Cancer Res       Date:  2016-01-07       Impact factor: 12.701

Review 5.  NK cells in HIV-1 infection: evidence for their role in the control of HIV-1 infection.

Authors:  G Alter; M Altfeld
Journal:  J Intern Med       Date:  2009-01       Impact factor: 8.989

6.  KIR3DL1 Allelic Polymorphism and HLA-B Epitopes Modulate Response to Anti-GD2 Monoclonal Antibody in Patients With Neuroblastoma.

Authors:  Christopher J Forlenza; Jeanette E Boudreau; Junting Zheng; Jean-Benoît Le Luduec; Elizabeth Chamberlain; Glenn Heller; Nai-Kong V Cheung; Katharine C Hsu
Journal:  J Clin Oncol       Date:  2016-04-11       Impact factor: 44.544

7.  Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection.

Authors:  J R Vidal-Castiñeira; A López-Vázquez; R Díaz-Peña; R Alonso-Arias; J Martínez-Borra; R Pérez; J Fernández-Suárez; S Melón; J Prieto; L Rodrigo; C López-Larrea
Journal:  J Virol       Date:  2010-01       Impact factor: 5.103

8.  Ly49 cluster sequence analysis in a mouse model of diabetes: an expanded repertoire of activating receptors in the NOD genome.

Authors:  S Belanger; L-H Tai; S K Anderson; A P Makrigiannis
Journal:  Genes Immun       Date:  2008-06-05       Impact factor: 2.676

Review 9.  A comparative review of HLA associations with hepatitis B and C viral infections across global populations.

Authors:  Rashmi Singh; Rashmi Kaul; Anil Kaul; Khalid Khan
Journal:  World J Gastroenterol       Date:  2007-03-28       Impact factor: 5.742

Review 10.  The immunobiology of primary sclerosing cholangitis.

Authors:  Jonathan H Aron; Christopher L Bowlus
Journal:  Semin Immunopathol       Date:  2009-05-26       Impact factor: 9.623
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