Literature DB >> 1594262

Diclofenac does not modify morphine bioavailability in cancer patients.

Franco De Conno1, Carla Ripamonti, Mauro Bianchi, Vittorio Ventafridda, Alberto E Panerai.   

Abstract

We determined morphine plasma concentrations in 6 cancer patients before and with administration of diclofenac for 5 days. The non-steroidal anti-inflammatory drug does not modify morphine bioavailability. This observation suggests that diclofenac can be used in association with morphine during cancer pain treatment, without increasing the risk of overdosage or side effects of the opiate.

Entities:  

Mesh:

Substances:

Year:  1992        PMID: 1594262     DOI: 10.1016/0304-3959(92)90091-O

Source DB:  PubMed          Journal:  Pain        ISSN: 0304-3959            Impact factor:   6.961


  2 in total

1.  Nimesulide and diclofenac in the control of cancer-related pain. Comparison between oral and rectal administration.

Authors:  O Corli; A Cozzolino; I Scaricabarozzi
Journal:  Drugs       Date:  1993       Impact factor: 9.546

Review 2.  Pharmacokinetic-pharmacodynamic drug interactions with nonsteroidal anti-inflammatory drugs.

Authors:  J R Brouwers; P A de Smet
Journal:  Clin Pharmacokinet       Date:  1994-12       Impact factor: 6.447

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.