BACKGROUND: The aim of this study was to evaluate some hypotheses about factors related to the development of type 1 diabetes mellitus. METHODS: A case-control study was conducted in Belgrade during the period 1994-1997. A total of 105 recently onset diabetic and 210 control children, individually matched by age (+/-1 year), sex and place of residence, were included in the study. RESULTS: According to multivariate regression analysis, the following factors were related to type 1 diabetes: stressful events and symptoms of psychological dysfunction during the 12 months preceding the onset of the disease [odds ratio (OR) 3.48, 95% confidence interval (CI) 2.15-5.65; and OR 2.15, 95% CI 1.33-3.48], irregular vaccination (OR 16.98, 95% CI 1.38-208.92), infection during 6 months preceding the onset of the disease (OR 4.23, 95% CI 1.95-9.17), higher education of father (OR 1.50, 95% CI 1.05-2.14), mother's consumption of nitrosoamines-rich food during pregnancy (OR 4.33, 95% CI 1.95-9.61), alcohol consumption by father (OR 3.80, 95% CI 1.64-8.78), insulin-dependent and non-insulin-dependent diabetes mellitus in three generations of children's relatives (OR 20.04, 95% CI 4.73-84.81; and OR 5.52, 95% CI 2.45-12.46), and use of ultrasound diagnostic techniques during pregnancy (OR 0.42, 95% CI 0.17-1.00). CONCLUSIONS: Among non-genetic factors, those affecting the child during pregnancy are especially important because of their preventability.
BACKGROUND: The aim of this study was to evaluate some hypotheses about factors related to the development of type 1 diabetes mellitus. METHODS: A case-control study was conducted in Belgrade during the period 1994-1997. A total of 105 recently onset diabetic and 210 control children, individually matched by age (+/-1 year), sex and place of residence, were included in the study. RESULTS: According to multivariate regression analysis, the following factors were related to type 1 diabetes: stressful events and symptoms of psychological dysfunction during the 12 months preceding the onset of the disease [odds ratio (OR) 3.48, 95% confidence interval (CI) 2.15-5.65; and OR 2.15, 95% CI 1.33-3.48], irregular vaccination (OR 16.98, 95% CI 1.38-208.92), infection during 6 months preceding the onset of the disease (OR 4.23, 95% CI 1.95-9.17), higher education of father (OR 1.50, 95% CI 1.05-2.14), mother's consumption of nitrosoamines-rich food during pregnancy (OR 4.33, 95% CI 1.95-9.61), alcohol consumption by father (OR 3.80, 95% CI 1.64-8.78), insulin-dependent and non-insulin-dependent diabetes mellitus in three generations of children's relatives (OR 20.04, 95% CI 4.73-84.81; and OR 5.52, 95% CI 2.45-12.46), and use of ultrasound diagnostic techniques during pregnancy (OR 0.42, 95% CI 0.17-1.00). CONCLUSIONS: Among non-genetic factors, those affecting the child during pregnancy are especially important because of their preventability.
Authors: S Sipetic; J Maksimovic; H Vlajinac; I Ratkov; S Sajic; D Zdravkovic; T Sipetic Journal: J Endocrinol Invest Date: 2012-09-24 Impact factor: 4.256
Authors: C R Cardwell; L C Stene; G Joner; O Cinek; J Svensson; M J Goldacre; R C Parslow; P Pozzilli; G Brigis; D Stoyanov; B Urbonaite; S Sipetić; E Schober; C Ionescu-Tirgoviste; G Devoti; C E de Beaufort; K Buschard; C C Patterson Journal: Diabetologia Date: 2008-02-22 Impact factor: 10.122
Authors: C R Cardwell; L C Stene; G Joner; E A Davis; O Cinek; J Rosenbauer; J Ludvigsson; C Castell; J Svensson; M J Goldacre; T Waldhoer; J Polanska; S G A Gimeno; L-M Chuang; R C Parslow; E J K Wadsworth; A Chetwynd; P Pozzilli; G Brigis; B Urbonaite; S Sipetić; E Schober; C Ionescu-Tirgoviste; C E de Beaufort; D Stoyanov; K Buschard; C C Patterson Journal: Diabetologia Date: 2010-01-10 Impact factor: 10.122
Authors: Geertruida J van Woudenbergh; Anneleen Kuijsten; Basia Tigcheler; Eric J G Sijbrands; Frank J A van Rooij; Albert Hofman; Jacqueline C M Witteman; Edith J M Feskens Journal: Diabetes Care Date: 2012-05-17 Impact factor: 19.112
Authors: Chris R Cardwell; Lars C Stene; Geir Joner; Max K Bulsara; Ondrej Cinek; Joachim Rosenbauer; Johnny Ludvigsson; Mireia Jané; Jannet Svensson; Michael J Goldacre; Thomas Waldhoer; Przemyslawa Jarosz-Chobot; Suely G A Gimeno; Lee-Ming Chuang; Roger C Parslow; Emma J K Wadsworth; Amanda Chetwynd; Paolo Pozzilli; Girts Brigis; Brone Urbonaite; Sandra Sipetic; Edith Schober; Gabriele Devoti; Constantin Ionescu-Tirgoviste; Carine E de Beaufort; Denka Stoyanov; Karsten Buschard; Chris C Patterson Journal: Diabetes Date: 2009-10-29 Impact factor: 9.461