AIM OF THE STUDY: To investigate the morphology of erythrocytes in the peripheral blood of patients with ovarian cancer stage II and III. MATERIALS AND METHODS: The patient group consisted of 17 women (age 53 +/- 16 years) diagnosed with stage II or II ovarian cancer. The control group comprised 20 healthy women (age 20 +/- 2 years). Seventeen samples of peripheral venous blood were collected from the cancer patients and 20 from the healthy women. These were then prepared for observation by scanning electron microscopy. RESULTS: The percentages of knizocytes and echinocytes were higher in the blood of patients than in that of the healthy controls. For knizocytes, the values for the mean +/- SD and the range were 2.45 +/- 3.72 and 0-15.7 vs. 0.66 +/- 0.57, 0.1-2.5, with p < 0.01. For echinocytes, these values were 1.94 +/- 1.04 and 0.5-3.6 vs. 1.03 +/- 0.71, 0.1-2.6 and p < 0.01. Acanthocytes were present only in small numbers and were not evaluated. CONCLUSION: The proportion of erythrocytes with abnormal morphology in the blood of cancer patients before cancer therapy was significantly elevated as compared to that healthy controls.
AIM OF THE STUDY: To investigate the morphology of erythrocytes in the peripheral blood of patients with ovarian cancer stage II and III. MATERIALS AND METHODS: The patient group consisted of 17 women (age 53 +/- 16 years) diagnosed with stage II or II ovarian cancer. The control group comprised 20 healthy women (age 20 +/- 2 years). Seventeen samples of peripheral venous blood were collected from the cancerpatients and 20 from the healthy women. These were then prepared for observation by scanning electron microscopy. RESULTS: The percentages of knizocytes and echinocytes were higher in the blood of patients than in that of the healthy controls. For knizocytes, the values for the mean +/- SD and the range were 2.45 +/- 3.72 and 0-15.7 vs. 0.66 +/- 0.57, 0.1-2.5, with p < 0.01. For echinocytes, these values were 1.94 +/- 1.04 and 0.5-3.6 vs. 1.03 +/- 0.71, 0.1-2.6 and p < 0.01. Acanthocytes were present only in small numbers and were not evaluated. CONCLUSION: The proportion of erythrocytes with abnormal morphology in the blood of cancerpatients before cancer therapy was significantly elevated as compared to that healthy controls.
Authors: Christian P Nixon; Ari W Satyagraha; Grayson L Baird; Alida R Harahap; Lydia V Panggalo; Lenny L Ekawati; Inge Sutanto; Din Syafruddin; J Kevin Baird Journal: Int J Lab Hematol Date: 2018-07-13 Impact factor: 2.877