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Literature DB >> 15940654

Protease inhibitors in acute pancreatitis: lessons from the bench and failed clinical trials.

Vijay P Singh, Suresh T Chari.

Abstract

Entities: Disease

Year: 2005 PMID： 15940654 DOI： 10.1053/j.gastro.2005.03.087

Source DB: PubMed Journal: Gastroenterology ISSN： 0016-5085 Impact factor: 22.682

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10 in total

1. Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion.

Authors: Vijay P Singh; Lakshmi Bhagat; Sarah Navina; Rifat Sharif; Rajinder K Dawra; Ashok K Saluja
Journal: Gut Date: 2006-11-17 Impact factor: 23.059

2. Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H.

Authors: Fu Gui; Yuebo Zhang; Jianhua Wan; Xianbao Zhan; Yao Yao; Yinghua Li; Ashley N Haddock; Ji Shi; Jia Guo; Jiaxiang Chen; Xiaohui Zhu; Brandy H Edenfield; Lu Zhuang; Cheng Hu; Ying Wang; Debabrata Mukhopadhyay; Evette S Radisky; Lizhi Zhang; Aurelia Lugea; Stephen J Pandol; Yan Bi; Baoan Ji
Journal: J Clin Invest Date: 2020-01-02 Impact factor: 14.808

3. Digesting new information about the role of trypsin in pancreatitis.

Authors: Baoan Ji; Craig D Logsdon
Journal: Gastroenterology Date: 2011-10-25 Impact factor: 22.682

Review 4. Relevance of animal models of pancreatic cancer and pancreatitis to human disease.

Authors: Ashok K Saluja; Vikas Dudeja
Journal: Gastroenterology Date: 2013-06 Impact factor: 22.682

Review 5. Regeneration and repair of the exocrine pancreas.

Authors: L Charles Murtaugh; Matthew D Keefe
Journal: Annu Rev Physiol Date: 2014-10-24 Impact factor: 19.318

6. Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis.

Authors: Rajinder Dawra; Raghuwansh P Sah; Vikas Dudeja; Loveena Rishi; Rupjoyti Talukdar; Pramod Garg; Ashok K Saluja
Journal: Gastroenterology Date: 2011-08-27 Impact factor: 22.682

Protease inhibitors in acute pancreatitis: lessons from the bench and failed clinical trials.

1. Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion.

2. Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H.

3. Digesting new information about the role of trypsin in pancreatitis.

Review 4. Relevance of animal models of pancreatic cancer and pancreatitis to human disease.

Review 5. Regeneration and repair of the exocrine pancreas.

6. Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis.

Review 7. New insights into the pathogenesis of pancreatitis.

Review 8. The role of protein synthesis and digestive enzymes in acinar cell injury.

Review 9. Central role of neutrophil in the pathogenesis of severe acute pancreatitis.

Review 10. Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis.