C M Chu1, Y F Liaw. 1. Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, 199 Tung Hwa North Road, Taipei 105, Taiwan, chu0066@cgmh.org.tw
Abstract
BACKGROUND: Previous studies have shown a high risk of fulminant hepatitis in HBsAg carriers with acute hepatitis. The etiology of acute hepatitis in HBsAg carriers was heterogeneous. This study aimed to correlate the incidence of fulminant hepatitis with the etiology in HBsAg carriers with acute hepatitis. PATIENTS AND METHODS: The incidence of fulminant hepatitis was studied in 334 adults hospitalized for overt acute viral hepatitis. There were 12 patients with acute hepatitis A, 17 with acute hepatitis B, 70 with acute hepatitis C, five with acute hepatitis E, 53 with acute hepatitis non-A-E, and 177 previously unrecognized HBsAg carriers with acute hepatitis (patients who were positive for HBsAg but negative for IgM antibody against hepatitis B core antigen). Of the latter, 64 (36%) had serological evidence of non-B hepatotropic virus superinfection. RESULTS: The incidence of fulminant hepatitis was 3.2% (5/157) in patients with acute hepatitis A, B, C, E or non-A-E, and 20.3% (36/177) in HBsAg carriers with acute hepatitis (p < 0.001). HBsAg carriers were at a 9-fold increased risk of fulminant hepatitis than noncarriers. Among HBsAg carriers with acute hepatitis, the incidence of fulminant hepatitis showed no significant difference between patients with viral superinfection (23% or 15/64) and those without (19% or 21/113). The incidence of fulminant hepatitis in HBsAg carriers with viral superinfection also showed no significant difference between different etiologies of virus superinfection. CONCLUSION: There is a 9-fold increased risk of fulminant hepatitis in HBsAg carriers with acute hepatitis, independent of the underlying etiology.
BACKGROUND: Previous studies have shown a high risk of fulminant hepatitis in HBsAg carriers with acute hepatitis. The etiology of acute hepatitis in HBsAg carriers was heterogeneous. This study aimed to correlate the incidence of fulminant hepatitis with the etiology in HBsAg carriers with acute hepatitis. PATIENTS AND METHODS: The incidence of fulminant hepatitis was studied in 334 adults hospitalized for overt acute viral hepatitis. There were 12 patients with acute hepatitis A, 17 with acute hepatitis B, 70 with acute hepatitis C, five with acute hepatitis E, 53 with acute hepatitisnon-A-E, and 177 previously unrecognized HBsAg carriers with acute hepatitis (patients who were positive for HBsAg but negative for IgM antibody against hepatitis B core antigen). Of the latter, 64 (36%) had serological evidence of non-B hepatotropic virus superinfection. RESULTS: The incidence of fulminant hepatitis was 3.2% (5/157) in patients with acute hepatitis A, B, C, E or non-A-E, and 20.3% (36/177) in HBsAg carriers with acute hepatitis (p < 0.001). HBsAg carriers were at a 9-fold increased risk of fulminant hepatitis than noncarriers. Among HBsAg carriers with acute hepatitis, the incidence of fulminant hepatitis showed no significant difference between patients with viral superinfection (23% or 15/64) and those without (19% or 21/113). The incidence of fulminant hepatitis in HBsAg carriers with viral superinfection also showed no significant difference between different etiologies of virus superinfection. CONCLUSION: There is a 9-fold increased risk of fulminant hepatitis in HBsAg carriers with acute hepatitis, independent of the underlying etiology.
Authors: Joo Il Kim; Yun Soo Kim; Young Kul Jung; Oh Sang Kwon; Yeon Suk Kim; Yang Suh Ku; Duck Joo Choi; Ju Hyun Kim Journal: Korean J Hepatol Date: 2010-09
Authors: Sang Ho Lee; Hyoung Su Kim; Kwon Oh Park; Jong Won Park; Seung Yeon Chun; Seung Jin Lim; Hyun Jung Cho; Sung Jun Kim; Hye Won Park; Han Kook Moon; Woon Geon Shin; Kyung Ho Kim; Myoung Kuk Jang; Jin Heon Lee; Hak Yang Kim Journal: Korean J Hepatol Date: 2010-12
Authors: So Young Kwon; Sang Hoon Park; Jong Eun Yeon; Sook Hyang Jeong; Oh Sang Kwon; Jin Woo Lee; Hong Soo Kim; Yeon Seok Seo; Young Seok Kim; Joo Hyun Sohn; Hyung Joon Yim; Jong Young Choi; Myung Seok Lee; Young Oh Kweon; Jae Youn Cheong; Haak Cheoul Kim; Heon Ju Lee; Soon Koo Baik; Hyonggin An; Kwan Soo Byun Journal: J Korean Med Sci Date: 2014-01-28 Impact factor: 2.153