| Literature DB >> 15940393 |
Shiro Maeda1, Shuichi Tsukada2, Akio Kanazawa2, Akihiro Sekine3, Tatsuhiko Tsunoda4, Daisuke Koya5, Hiroshi Maegawa5, Atsunori Kashiwagi5, Tetsuya Babazono6, Masafumi Matsuda7, Yasushi Tanaka8, Tomoaki Fujioka9, Hiroshi Hirose10, Takashi Eguchi10, Yoichi Ohno10, Christopher J Groves11,12, Andrew T Hattersley13, Graham A Hitman14, Mark Walker15, Kohei Kaku7, Yasuhiko Iwamoto6, Ryuzo Kawamori8, Ryuichi Kikkawa5, Naoyuki Kamatani16,17, Mark I McCarthy11,12, Yusuke Nakamura17,18.
Abstract
To search a gene(s) conferring susceptibility to type 2 diabetes mellitus, we genotyped nearly 60,000 gene-based SNPs for Japanese patients and found evidence that the gene at chromosome 6p12 encoding transcription-factor-activating protein 2beta (TFAP2B) was a likely candidate in view of significant association of polymorphism in this gene with type 2 diabetes. Extensive analysis of this region identified that several variations within TFAP2B were significantly associated with type 2 diabetes [a variable number of tandem repeat locus: chi(2)=10.9, P=0.0009; odds ratio=1.57, 95% CI 1.20-2.06, intron 1+774 (G/T); chi(2)=11.6, P=0.0006; odds ratio=1.60, 95% CI 1.22-2.09, intron 1+2093 (A/C); chi(2)=12.2, P=0.0004; odds ratio=1.61, 95% CI 1.23-2.11]. The association of TFAP2B with type 2 diabetes was also observed in the UK population. These results suggest that TFAP2B might be a new candidate for conferring susceptibility to type 2 diabetes and contribute to the pathogenesis of type 2 diabetes.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15940393 DOI： 10.1007/s10038-005-0253-9
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172