OBJECTIVE: Hyperhomocysteinemia is associated with atherosclerotic risk. Although vitamins can lower homocysteine (Hcy), information about effects on atherosclerosis is scarce. METHODS: We used carotid intima-media thickness (IMT) as an accepted marker of atherosclerotic changes. Fifty patients (60 +/- 8 years) with IMT>; or =1 mm were included. In a double blind, randomized trial they received daily 2.5 mg folic acid, 25 mg Vitamin B6, and 0.5mg Vitamin B12 or placebo for 1 year. RESULTS: In the treatment group, Hcy decreased from 10.50 +/- 3.93 to 6.56 +/- 1.53 micromol/l (P < 0.0001), whereas it remained unchanged in the placebo group (10.76 +/- 2.36 versus 10.45+/-3.30 micromol/l). IMT decreased from 1.50 +/- 0.44 to 1.42 +/- 0.48 mm (P = 0.034) in the treatment group, whereas it increased from 1.47 +/- 0.57 to 1.54 +/- 0.71 mm in the placebo group. The mean individual changes of IMT between both groups differed significantly (-0.08 +/- 0.17 versus 0.07 +/- 0.25 mm, P = 0.019). Multiple regression analysis revealed that the observed effect on IMT depended only on medication. CONCLUSIONS:Vitamin supplementation significantly reduces IMT in patients at risk. This effect is independent of Hcy concentration.
RCT Entities:
OBJECTIVE:Hyperhomocysteinemia is associated with atherosclerotic risk. Although vitamins can lower homocysteine (Hcy), information about effects on atherosclerosis is scarce. METHODS: We used carotid intima-media thickness (IMT) as an accepted marker of atherosclerotic changes. Fifty patients (60 +/- 8 years) with IMT> or =1 mm were included. In a double blind, randomized trial they received daily 2.5 mg folic acid, 25 mg Vitamin B6, and 0.5mg Vitamin B12 or placebo for 1 year. RESULTS: In the treatment group, Hcy decreased from 10.50 +/- 3.93 to 6.56 +/- 1.53 micromol/l (P < 0.0001), whereas it remained unchanged in the placebo group (10.76 +/- 2.36 versus 10.45+/-3.30 micromol/l). IMT decreased from 1.50 +/- 0.44 to 1.42 +/- 0.48 mm (P = 0.034) in the treatment group, whereas it increased from 1.47 +/- 0.57 to 1.54 +/- 0.71 mm in the placebo group. The mean individual changes of IMT between both groups differed significantly (-0.08 +/- 0.17 versus 0.07 +/- 0.25 mm, P = 0.019). Multiple regression analysis revealed that the observed effect on IMT depended only on medication. CONCLUSIONS: Vitamin supplementation significantly reduces IMT in patients at risk. This effect is independent of Hcy concentration.
Authors: Susan J Duthie; John H Beattie; Margaret-J Gordon; Lynn P Pirie; Fergus Nicol; Martin D Reid; Gary J Duncan; Louise Cantlay; Graham Horgan; Christopher J McNeil Journal: Genes Nutr Date: 2014-12-02 Impact factor: 5.523
Authors: Alberto Mazza; Stefano Cuppini; Laura Schiavon; Marco Zuin; Roberta Ravenni; Giulia Balbi; Domenico Montemurro; Giuseppe Opocher; Maria Rosa Pelizzo; Patrick M Colletti; Domenico Rubello Journal: Endocrine Date: 2013-10-03 Impact factor: 3.633
Authors: Howard N Hodis; Wendy J Mack; Laurie Dustin; Peter R Mahrer; Stanley P Azen; Robert Detrano; Jacob Selhub; Petar Alaupovic; Chao-ran Liu; Ci-hua Liu; Juliana Hwang; Alison G Wilcox; Robert H Selzer Journal: Stroke Date: 2008-12-31 Impact factor: 7.914
Authors: Kathleen Potter; Graeme J Hankey; Daniel J Green; John Eikelboom; Konrad Jamrozik; Leonard F Arnolda Journal: BMC Cardiovasc Disord Date: 2008-09-20 Impact factor: 2.298
Authors: Katarzyna Goszcz; Sherine J Deakin; Garry G Duthie; Derek Stewart; Stephen J Leslie; Ian L Megson Journal: Front Cardiovasc Med Date: 2015-07-06