Literature DB >> 15937482

Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia.

Takaharu Taketomi1, Daigo Yoshiga, Koji Taniguchi, Takashi Kobayashi, Atsushi Nonami, Reiko Kato, Mika Sasaki, Atsuo Sasaki, Hitoshi Ishibashi, Maiko Moriyama, Kei-ichiro Nakamura, Junji Nishimura, Akihiko Yoshimura.   

Abstract

We report here that loss of the Sprouty2 gene (also known as Spry2) in mice resulted in enteric nerve hyperplasia, which led to esophageal achalasia and intestinal pseudo-obstruction. Glial cell line-derived neurotrophic factor (GDNF) induced hyperactivation of ERK and Akt in enteric nerve cells. Anti-GDNF antibody administration corrected nerve hyperplasia in Sprouty2-deficient mice. We show Sprouty2 to be a negative regulator of GDNF for the neonatal development or survival of enteric nerve cells.

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Year:  2005        PMID： 15937482     DOI： 10.1038/nn1485

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  52 in total

1.  Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes.

Authors:  Tiffany A Heanue; Vassilis Pachnis
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-21       Impact factor: 11.205

2.  Sprouty2 downregulates angiogenesis during mouse skin wound healing.

Authors:  Mateusz S Wietecha; Lin Chen; Matthew J Ranzer; Kimberly Anderson; Chunyi Ying; Tarun B Patel; Luisa A DiPietro
Journal:  Am J Physiol Heart Circ Physiol       Date:  2010-11-12       Impact factor: 4.733

Review 3.  Enteric nervous system development: A crest cell's journey from neural tube to colon.

Authors:  Nandor Nagy; Allan M Goldstein
Journal:  Semin Cell Dev Biol       Date:  2017-01-10       Impact factor: 7.727

Review 4.  Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease.

Authors:  G Burzynski; I T Shepherd; H Enomoto
Journal:  Neurogastroenterol Motil       Date:  2009-02       Impact factor: 3.598

Review 5.  Receptor tyrosine kinase (RTK) signalling in the control of neural stem and progenitor cell (NSPC) development.

Authors:  Alexander Annenkov
Journal:  Mol Neurobiol       Date:  2013-08-28       Impact factor: 5.590

6.  Gastrointestinal dysfunction in autism displayed by altered motility and achalasia in Foxp1 +/- mice.

Authors:  Henning Fröhlich; Marie Luise Kollmeyer; Valerie Catherine Linz; Manuel Stuhlinger; Dieter Groneberg; Amelie Reigl; Eugen Zizer; Andreas Friebe; Beate Niesler; Gudrun Rappold
Journal:  Proc Natl Acad Sci U S A       Date:  2019-10-14       Impact factor: 11.205

7.  Modifier variant of METTL13 suppresses human GAB1-associated profound deafness.

Authors:  Rizwan Yousaf; Zubair M Ahmed; Arnaud Pj Giese; Robert J Morell; Ayala Lagziel; Alain Dabdoub; Edward R Wilcox; Sheikh Riazuddin; Thomas B Friedman; Saima Riazuddin
Journal:  J Clin Invest       Date:  2018-03-12       Impact factor: 14.808

8.  Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program.

Authors:  Mounia Lagha; Jay D Kormish; Didier Rocancourt; Marie Manceau; Jonathan A Epstein; Kenneth S Zaret; Frédéric Relaix; Margaret E Buckingham
Journal:  Genes Dev       Date:  2008-07-01       Impact factor: 11.361

9.  Sprouty4 interferes with cell proliferation and migration of breast cancer-derived cell lines.

Authors:  Vanita Vanas; Elsa Mühlbacher; Rosana Kral; Hedwig Sutterlüty-Fall
Journal:  Tumour Biol       Date:  2014-01-09

10.  Loss of Sprouty1 rescues renal agenesis caused by Ret mutation.

Authors:  Esteban J Rozen; Hagen Schmidt; Xavier Dolcet; M Albert Basson; Sanjay Jain; Mario Encinas
Journal:  J Am Soc Nephrol       Date:  2008-12-03       Impact factor: 10.121
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