| Literature DB >> 15936683 |
B Bert1, E Dere, N Wilhelmi, H Kusserow, F Theuring, J P Huston, H Fink.
Abstract
Previously, we showed that mice that overexpress the 5-HT(1A) receptor transiently from embryonic to perinatal stages show reduced anxiety and changes in brain serotonin turnover as adults. Here, we investigated the long-term effects of the temporary overexpression of the 5-HT(1A) receptor during early embryonic and perinatal development on the performance in two memory tasks. In the hole-board test mice that were homozygous for the transgene showed similar behavioral habituation but increased locomotion compared to heterozygous mice. In contrast water-maze performance of homozygous mice was impaired compared to heterozygous mice. These results suggest that a transient overexpression of 5-HT(1A) receptor during embryonic and perinatal development has detrimental effects on water-maze performance at adult stages.Entities:
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Year: 2005 PMID： 15936683 DOI： 10.1016/j.nlm.2005.03.005
Source DB: PubMed Journal: Neurobiol Learn Mem ISSN： 1074-7427 Impact factor: 2.877