PURPOSE: To evaluate the effect of an ipsilateral breast tumor recurrence (IBTR) after breast-conservation therapy (BCT) on survival. METHODS AND MATERIALS: One hundred twenty-one women were randomized to BCT. Patients with an IBTR were analyzed to determine survival. Analysis was performed with Kaplan-Meier estimates, log-rank tests, and time-dependent covariate Cox models. RESULTS: At a median follow-up of 18.4 years, 27 patients had an IBTR. The median survival time after IBTR was 13.1 years. The 5-year survival rate was 91.8% (95% confidence interval [CI], 81.5-100%). The 10-year survival rate was 54.3% (95% CI, 35.8-82.6%). According to a Cox model with time-dependent covariates, the hazard ratio or relative risk of dying for those with an IBTR at <5.3 years after BCT relative to patients without an IBTR after BCT is 1.47 (95% CI, 1.02-2.12%; p = 0.04). The hazard ratio for those who relapse after 5.3 years is 0.59 (95% CI, 0.22-1.61%; p = 0.31). Age at randomization, original tumor size, and the presence of positive regional nodes at initial presentation were not found to be associated with decreased survival. CONCLUSIONS: There seems to be a significant association of early IBTR after BCT with decreased survival. Local control should be maximized.
RCT Entities:
PURPOSE: To evaluate the effect of an ipsilateral breast tumor recurrence (IBTR) after breast-conservation therapy (BCT) on survival. METHODS AND MATERIALS: One hundred twenty-one women were randomized to BCT. Patients with an IBTR were analyzed to determine survival. Analysis was performed with Kaplan-Meier estimates, log-rank tests, and time-dependent covariate Cox models. RESULTS: At a median follow-up of 18.4 years, 27 patients had an IBTR. The median survival time after IBTR was 13.1 years. The 5-year survival rate was 91.8% (95% confidence interval [CI], 81.5-100%). The 10-year survival rate was 54.3% (95% CI, 35.8-82.6%). According to a Cox model with time-dependent covariates, the hazard ratio or relative risk of dying for those with an IBTR at <5.3 years after BCT relative to patients without an IBTR after BCT is 1.47 (95% CI, 1.02-2.12%; p = 0.04). The hazard ratio for those who relapse after 5.3 years is 0.59 (95% CI, 0.22-1.61%; p = 0.31). Age at randomization, original tumor size, and the presence of positive regional nodes at initial presentation were not found to be associated with decreased survival. CONCLUSIONS: There seems to be a significant association of early IBTR after BCT with decreased survival. Local control should be maximized.
Authors: T Onega; W Zhu; J E Weiss; M Goodrich; A N A Tosteson; W DeMartini; B A Virnig; L M Henderson; D S M Buist; K J Wernli; K Kerlikowske; R A Hubbard Journal: Breast Cancer Res Treat Date: 2018-03-07 Impact factor: 4.872
Authors: M Massaccesi; C Digesù; G Macchia; F Deodato; M Ciuffreda; E Cucci; L Caravatta; G Corrado; G D A Padula; R De Vizia; N Cellini; V Valentini; G Sallustio; G Ferrandina; F Pacelli; A G Morganti Journal: Br J Radiol Date: 2012-02-14 Impact factor: 3.039
Authors: F Sedlmayer; M-L Sautter-Bihl; W Budach; J Dunst; G Fastner; P Feyer; R Fietkau; W Haase; W Harms; R Souchon; F Wenz; R Sauer Journal: Strahlenther Onkol Date: 2013-10 Impact factor: 3.621
Authors: Felix Sedlmayer; Roland Reitsamer; Christoph Fussl; Ingrid Ziegler; Franz Zehentmayr; Heinz Deutschmann; Peter Kopp; Gerd Fastner Journal: Int J Breast Cancer Date: 2014-09-02
Authors: Felix Sedlmayer; Roland Reitsamer; Frederik Wenz; Elena Sperk; Christoph Fussl; Julia Kaiser; Ingrid Ziegler; Franz Zehentmayr; Heinz Deutschmann; Peter Kopp; Gerd Fastner Journal: Radiat Oncol Date: 2017-01-19 Impact factor: 3.481