Synthesis of N-(4-bromo-2-trifluoromethylphenyl)-1-(2-fluorophenyl)-O,O-dialkyl-alpha-aminophosphonates under ultrasonic irradiation.

Boron trifluoride diethyl etherate catalyzes the Mannich-type reaction of 2-trifluoromethyl-4-bromoaniline and O,O-dialkylphosphite with 2-fluorobenzoaldehyde under ultrasonic irradiation to synthesize the corresponding product alpha-aminophosphonate. The advantages of the procedure include short reaction period, high yield and simple working up. Their structures were clearly established by IR, (1)H NMR, (13)C NMR and elemental analysis. The bioassay tests showed that the title compounds exhibit moderate antitumor activity in vitro by MTT method.