| Literature DB >> 15936202 |
Maria Grazia Ferlin1, Christine Marzano, Lisa Dalla Via, Adriana Chilin, Giuseppe Zagotto, Adriano Guiotto, Stefano Moro.
Abstract
A new class of water soluble 3H-pyrrolo[3,2-f]quinoline derivatives has been synthesized and investigated as potential anticancer drugs. Water solubility profiles have been used to select the most promising derivatives. The novel compound 10, having two (2-diethylamino-ethyl) side chains linked through positions 3N and 9O, presents a suitable water solubility profile, and it was shown to exhibit cell growth inhibitory properties when tested against the in-house panel of cell lines, in particular those obtained from melanoma.Entities:
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Year: 2005 PMID： 15936202 DOI： 10.1016/j.bmc.2005.04.080
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641