| Literature DB >> 15935680 |
Gianluca Bianchini1, Massimiliano Aschi, Giancarlo Cavicchio, Marcello Crucianelli, Serena Preziuso, Carlo Gallina, Adele Nastari, Enrico Gavuzzo, Fernando Mazza.
Abstract
Three novel peptidomimetic phosphinate inhibitors have been synthesized and evaluated as inhibitors of matrix metalloproteinases MMP-2 and MMP-8. Their IC50 values are in the micromolar range, and one of them showed to be the most effective inhibitor of MMP-2. The differences in binding affinities for MMP-2 and MMP-8 of the three phosphinates have been rationalized by means of modelling studies and molecular dynamics simulations.Entities:
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Year: 2005 PMID： 15935680 DOI： 10.1016/j.bmc.2005.04.079
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641