| Literature DB >> 15935493 |
Konstantinos P Letsas, Antonios Sideris, Stavros P Kounas, Michalis Efremidis, Panagiotis Korantzopoulos, Fotios Kardaras.
Abstract
Several non-antiarrhythmic drugs including antibiotic and antipsychotic agents have been shown to prolong cardiac repolarization predisposing to torsade de pointes ventricular tachycardia. Blockade of the delayed rectifier (repolarising) potassium current and drug interactions with inhibitors of the CYP-mediated metabolism are the most common underlying mechanisms. In the present case report, an elderly woman receiving a long-term medication with azathioprine, olanzapine and valsartan developed a marked QT interval prolongation after intravenous administration of ciprofloxacin.Entities:
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Year: 2005 PMID： 15935493 DOI： 10.1016/j.ijcard.2005.04.031
Source DB: PubMed Journal: Int J Cardiol ISSN： 0167-5273 Impact factor: 4.164