INTRODUCTION: Several experimental and clinical studies have demonstrated that platelet size and function correlate since large platelets are hemostatically more reactive than platelets of normal size. Since platelets play a crucial role in vascular remodeling after percutaneous transluminal coronary angioplasty (PTCA), we investigated the influence of the mean platelet volume (MPV), a parameter of platelet size, on restenosis after PTCA. METHODS: The retrospective study comprised 174 patients who underwent elective PTCA and follow-up angiography within 6 months thereafter. According to the follow-up angiograms, the patients were assigned to group A ("restenosis", n=74) or group B ("no restenosis", n=100). Both groups were compared in regard to pre-procedural hematological routine parameters including MPV, platelet count, hematocrit, white blood cell count and fibrinogen. RESULTS: MPV was significantly increased in group A, compared with that in group B (8.75+/-0.99 fl vs. 8.04+/-0.74 fl, p<0.001). This difference in MPV was evident in patients with stable and unstable angina pectoris. In addition, MPV had an impact on the time-related incidence of angiographic restenosis, as early restenosis was associated with higher pre-procedural MPV values. Platelet count correlated inversely with MPV (r=-0.36, p<0.01) and was significantly lower in group A than in group B. The remaining hematological parameters were not different in both groups. CONCLUSIONS: The MPV seems to be a marker of coronary restenosis in patients undergoing PTCA. Patients with high pre-procedural MPV values might benefit from an intensified antiplatelet therapy after coronary interventions.
INTRODUCTION: Several experimental and clinical studies have demonstrated that platelet size and function correlate since large platelets are hemostatically more reactive than platelets of normal size. Since platelets play a crucial role in vascular remodeling after percutaneous transluminal coronary angioplasty (PTCA), we investigated the influence of the mean platelet volume (MPV), a parameter of platelet size, on restenosis after PTCA. METHODS: The retrospective study comprised 174 patients who underwent elective PTCA and follow-up angiography within 6 months thereafter. According to the follow-up angiograms, the patients were assigned to group A ("restenosis", n=74) or group B ("no restenosis", n=100). Both groups were compared in regard to pre-procedural hematological routine parameters including MPV, platelet count, hematocrit, white blood cell count and fibrinogen. RESULTS: MPV was significantly increased in group A, compared with that in group B (8.75+/-0.99 fl vs. 8.04+/-0.74 fl, p<0.001). This difference in MPV was evident in patients with stable and unstable angina pectoris. In addition, MPV had an impact on the time-related incidence of angiographic restenosis, as early restenosis was associated with higher pre-procedural MPV values. Platelet count correlated inversely with MPV (r=-0.36, p<0.01) and was significantly lower in group A than in group B. The remaining hematological parameters were not different in both groups. CONCLUSIONS: The MPV seems to be a marker of coronary restenosis in patients undergoing PTCA. Patients with high pre-procedural MPV values might benefit from an intensified antiplatelet therapy after coronary interventions.
Authors: Alok Ravindra Amraotkar; David Day Song; Diana Otero; Patrick James Trainor; Imtiaz Ismail; Vallari Kothari; Ayesha Singh; Joseph B Moore; Shesh Nath Rai; Andrew Paul DeFilippis Journal: Clin Appl Thromb Hemost Date: 2016-12-21 Impact factor: 2.389
Authors: S G Chu; R C Becker; P B Berger; D L Bhatt; J W Eikelboom; B Konkle; E R Mohler; M P Reilly; J S Berger Journal: J Thromb Haemost Date: 2009-08-19 Impact factor: 5.824
Authors: John F Martin; Steen D Kristensen; Anthony Mathur; Erik L Grove; Fizzah A Choudry Journal: Nat Rev Cardiol Date: 2012-11 Impact factor: 32.419
Authors: Nicole Soranzo; Tim D Spector; Massimo Mangino; Brigitte Kühnel; Augusto Rendon; Alexander Teumer; Christina Willenborg; Benjamin Wright; Li Chen; Mingyao Li; Perttu Salo; Benjamin F Voight; Philippa Burns; Roman A Laskowski; Yali Xue; Stephan Menzel; David Altshuler; John R Bradley; Suzannah Bumpstead; Mary-Susan Burnett; Joseph Devaney; Angela Döring; Roberto Elosua; Stephen E Epstein; Wendy Erber; Mario Falchi; Stephen F Garner; Mohammed J R Ghori; Alison H Goodall; Rhian Gwilliam; Hakon H Hakonarson; Alistair S Hall; Naomi Hammond; Christian Hengstenberg; Thomas Illig; Inke R König; Christopher W Knouff; Ruth McPherson; Olle Melander; Vincent Mooser; Matthias Nauck; Markku S Nieminen; Christopher J O'Donnell; Leena Peltonen; Simon C Potter; Holger Prokisch; Daniel J Rader; Catherine M Rice; Robert Roberts; Veikko Salomaa; Jennifer Sambrook; Stefan Schreiber; Heribert Schunkert; Stephen M Schwartz; Jovana Serbanovic-Canic; Juha Sinisalo; David S Siscovick; Klaus Stark; Ida Surakka; Jonathan Stephens; John R Thompson; Uwe Völker; Henry Völzke; Nicholas A Watkins; George A Wells; H-Erich Wichmann; David A Van Heel; Chris Tyler-Smith; Swee Lay Thein; Sekar Kathiresan; Markus Perola; Muredach P Reilly; Alexandre F R Stewart; Jeanette Erdmann; Nilesh J Samani; Christa Meisinger; Andreas Greinacher; Panos Deloukas; Willem H Ouwehand; Christian Gieger Journal: Nat Genet Date: 2009-10-11 Impact factor: 38.330
Authors: Binita Shah; Brandon Oberweis; Lakshmi Tummala; Nicholas S Amoroso; Iryna Lobach; Steven P Sedlis; Eugene Grossi; Jeffrey S Berger Journal: Am J Cardiol Date: 2012-10-24 Impact factor: 2.778