OBJECTIVE: To evaluate the significance of the expression of matrix metalloproteinases (MMPs) in prostate cancer (PCa) and its clinical association. METHODS: Fifty one cases of PCa and 10 cases of BPH were studied by immunohistochemical method using monoclonal antibodies to MMP2 and MMP9. RESULTS: There was significant correlation between MMP2 or MMP9 and pathological grade, Gleason score and PCa metastasis. CONCLUSION: The expression of MMP2 and MMP9 may play an important role in the development and metastasis of PCa.
OBJECTIVE: To evaluate the significance of the expression of matrix metalloproteinases (MMPs) in prostate cancer (PCa) and its clinical association. METHODS: Fifty one cases of PCa and 10 cases of BPH were studied by immunohistochemical method using monoclonal antibodies to MMP2 and MMP9. RESULTS: There was significant correlation between MMP2 or MMP9 and pathological grade, Gleason score and PCa metastasis. CONCLUSION: The expression of MMP2 and MMP9 may play an important role in the development and metastasis of PCa.