Literature DB >> 15934033

Antitumor activity of crude extract and fractions from root tuber of Cynanchum auriculatum Royle ex Wight.

Lei Shan1, Wei-Dong Zhang, Chuan Zhang, Run-Hui Liu, Juan Su, Yun Zhou.   

Abstract

Antitumor activity of the ethanol extract from the root tuber of Cynanchum auriculatum Royle ex Wight and four fractions of the ethanol extract were investigated, both in vitro and in vivo. The five samples exhibited cytotoxic activity on human tumor cell lines K562, SHG44, HCT-8, A549, PC3, in vitro and inhibition in mouse implanted sarcoma S180, in vivo. Among the five samples, fraction E was noted to be of the highest antitumor activity. Copyright 2005 John Wiley & Sons, Ltd.

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Year:  2005        PMID： 15934033     DOI： 10.1002/ptr.1678

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  9 in total

1.  A C 21 -Steroidal Glycoside Isolated from the Roots of Cynanchum auriculatum Induces Cell Cycle Arrest and Apoptosis in Human Gastric Cancer SGC-7901 Cells.

Authors:  Yi-Qi Wang; Shui-Juan Zhang; Hong Lu; Bo Yang; Liang-Fei Ye; Ru-Song Zhang
Journal:  Evid Based Complement Alternat Med       Date:  2013-12-19       Impact factor: 2.629

2.  An ethanol root extract of Cynanchum wilfordii containing acetophenones suppresses the expression of VCAM-1 and ICAM-1 in TNF-α-stimulated human aortic smooth muscle cells through the NF-κB pathway.

Authors:  Hyun Jung Koo; Eun-Hwa Sohn; Suhkneung Pyo; Han Goo Woo; Dae Won Park; Young-Min Ham; Seon-A Jang; Soo-Yeong Park; Se Chan Kang
Journal:  Int J Mol Med       Date:  2015-02-26       Impact factor: 4.101

3.  Cynanchum wilfordii Polysaccharides Suppress Dextran Sulfate Sodium-Induced Acute Colitis in Mice and the Production of Inflammatory Mediators from Macrophages.

Authors:  Chang-Won Cho; Sungeun Ahn; Tae-Gyu Lim; Hee-Do Hong; Young Kyoung Rhee; Deok-Chun Yang; Mi Jang
Journal:  Mediators Inflamm       Date:  2017-06-20       Impact factor: 4.711

4.  Baishouwu Extract Suppresses the Development of Hepatocellular Carcinoma via TLR4/MyD88/NF-κB Pathway.

Authors:  Yong-Fang Ding; Zi-Xuan Peng; Lan Ding; Yun-Ru Peng
Journal:  Front Pharmacol       Date:  2019-04-24       Impact factor: 5.810

5.  Cytotoxic and apoptosis-inducing properties of a C21-steroidal glycoside isolated from the roots of Cynanchum auriculatum.

Authors:  Liang-Fei Ye; Yi-Qi Wang; Bo Yang; Ru-Song Zhang
Journal:  Oncol Lett       Date:  2013-02-07       Impact factor: 2.967

6.  Immune-Enhancing Effects of a High Molecular Weight Fraction of Cynanchum wilfordii Hemsley in Macrophages and Immunosuppressed Mice.

Authors:  Mi Jang; Tae-Gyu Lim; Sungeun Ahn; Hee-Do Hong; Young Kyoung Rhee; Kyung-Tack Kim; Eunjung Lee; Jeong Hoon Lee; Yun Ji Lee; Chan Sik Jung; Dae Young Lee; Chang-Won Cho
Journal:  Nutrients       Date:  2016-09-27       Impact factor: 5.717

Review 7.  Ethnobotany, Phytochemistry and Pharmacological Effects of Plants in Genus Cynanchum Linn. (Asclepiadaceae).

Authors:  Lu Han; Xiuping Zhou; Mengmeng Yang; Li Zhou; Xinxin Deng; Shijie Wei; Wenping Wang; Zhizhong Wang; Xue Qiao; Changcai Bai
Journal:  Molecules       Date:  2018-05-16       Impact factor: 4.411

8.  Total C-21 steroidal glycosides, isolated from the root tuber of Cynanchum auriculatum Royle ex Wight, attenuate hydrogen peroxide-induced oxidative injury and inflammation in L02 cells.

Authors:  Zhenhui Wu; Yingyu Wang; Xian Meng; Xinjie Wang; Zhenlin Li; Shihui Qian; Yingjie Wei; Luan Shu; Yongfang Ding; Peijuan Wang; Yunru Peng
Journal:  Int J Mol Med       Date:  2018-09-25       Impact factor: 4.101

9.  Transcriptome analyses revealed molecular responses of Cynanchum auriculatum leaves to saline stress.

Authors:  Ming Zhang; Li-Zhou Hong; Min-Feng Gu; Cheng-Dong Wu; Gen Zhang
Journal:  Sci Rep       Date:  2020-01-16       Impact factor: 4.379
  9 in total

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