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Literature DB >> 15934014

Protective effect of a 50% hydroalcoholic fruit extract of Emblica officinalis against anti-tuberculosis drugs induced liver toxicity.

S A Tasduq¹, P Kaisar, D K Gupta, B K Kapahi, H S Maheshwari, S Jyotsna, R K Johri.

Abstract

The present report showed the hepatoprotective property of a 50% hydroalcoholic extract of the fruits of Emblica officinalis (fruit) (EO-50) against antituberculosis (anti-TB) drugs-induced hepatic injury. The biochemical manifestations of hepatotoxicity induced by rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA), either given alone or in combination were evaluated. In vitro studies were done on suspension cultures of rat hepatocytes while sub-acute studies were carried out in rats. The hepatoprotective activity of EO-50 was found to be due to its membrane stabilizing, antioxidative and CYP 2E1 inhibitory effects. Copyright 2005 John Wiley & Sons, Ltd.

Entities: Chemical Disease Gene Species

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Year: 2005 PMID： 15934014 DOI： 10.1002/ptr.1631

Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878

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Cited

10 in total

1. Negundoside, an irridiod glycoside from leaves of Vitex negundo, protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride.

Authors: Sheikh A Tasduq; Peerzada J Kaiser; Bishan D Gupta; Vijay K Gupta; Rakesh K Johri
Journal: World J Gastroenterol Date: 2008-06-21 Impact factor: 5.742

2. Effect of different oral doses of isoniazid-rifampicin in rats.

Authors: Satya V Rana; Ravinder Pal; Kim Vaiphie; Kartar Singh
Journal: Mol Cell Biochem Date: 2006-04-01 Impact factor: 3.396

3. Rifampicin exacerbates isoniazid-induced toxicity in human but not in rat hepatocytes in tissue-like cultures.

Authors: C Shen; Q Meng; G Zhang; W Hu
Journal: Br J Pharmacol Date: 2007-12-10 Impact factor: 8.739

4. Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs.

Authors: Meghna-R Adhvaryu; Narsimha Reddy; Minoo H Parabia
Journal: World J Gastroenterol Date: 2007-06-21 Impact factor: 5.742

Protective effect of a 50% hydroalcoholic fruit extract of Emblica officinalis against anti-tuberculosis drugs induced liver toxicity.

1. Negundoside, an irridiod glycoside from leaves of Vitex negundo, protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride.

2. Effect of different oral doses of isoniazid-rifampicin in rats.

3. Rifampicin exacerbates isoniazid-induced toxicity in human but not in rat hepatocytes in tissue-like cultures.

4. Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs.

5. Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach.

6. Genetic Variations Associated with Anti-Tuberculosis Drug-Induced Liver Injury.

7. Propolis prevents hepatorenal injury induced by chronic exposure to carbon tetrachloride.

8. Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats.

9. Hepatoprotective and antioxidant activity of standardized herbal extracts.

Review 10. Natural Medicines Used in the Traditional Tibetan Medical System for the Treatment of Liver Diseases.