Literature DB >> 15933191

Allosteric mechanisms of signal transduction.

Jean-Pierre Changeux1, Stuart J Edelstein.   

Abstract

Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and Changeux. We review the MWC theory and its applications for the understanding of signal transduction in biology, and also identify remaining issues that deserve theoretical and experimental substantiation.

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Year:  2005        PMID： 15933191     DOI： 10.1126/science.1108595

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  257 in total

1.  A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation.

Authors:  Meritxell Canals; J Robert Lane; Adriel Wen; Peter J Scammells; Patrick M Sexton; Arthur Christopoulos
Journal:  J Biol Chem       Date:  2011-11-15       Impact factor: 5.157

Review 2.  Regulation of hippocampal inhibitory circuits by nicotinic acetylcholine receptors.

Authors:  Marilena Griguoli; Enrico Cherubini
Journal:  J Physiol       Date:  2011-11-28       Impact factor: 5.182

Review 3.  What history tells us. XXVII. A new life for allostery.

Authors:  Michel Morange
Journal:  J Biosci       Date:  2012-03       Impact factor: 1.826

4.  Dynamical allosterism in the mechanism of action of DNA mismatch repair protein MutS.

Authors:  Susan N Pieniazek; Manju M Hingorani; D L Beveridge
Journal:  Biophys J       Date:  2011-10-05       Impact factor: 4.033

5.  Mechanisms of protein oligomerization, the critical role of insertions and deletions in maintaining different oligomeric states.

Authors:  Kosuke Hashimoto; Anna R Panchenko
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-03       Impact factor: 11.205

6.  Nucleosome-mediated cooperativity between transcription factors.

Authors:  Leonid A Mirny
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-13       Impact factor: 11.205

7.  Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors.

Authors:  Qian Wang; Stephan A Pless; Joseph W Lynch
Journal:  J Biol Chem       Date:  2010-10-11       Impact factor: 5.157

8.  Deconstructing thermodynamic parameters of a coupled system from site-specific observables.

Authors:  Sandipan Chowdhury; Baron Chanda
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-13       Impact factor: 11.205

9.  Disordered allostery: lessons from glucocorticoid receptor.

Authors:  Hesam N Motlagh; Jeremy A Anderson; Jing Li; Vincent J Hilser
Journal:  Biophys Rev       Date:  2015-04-23

10.  Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3.

Authors:  Debajyoti Datta; Christopher L McClendon; Matthew P Jacobson; James A Wells
Journal:  J Biol Chem       Date:  2013-02-05       Impact factor: 5.157
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